HERG K+ channels spike-frequency adaptation (Chiesa et al 1997)

 Download zip file 
Help downloading and running models
Accession:57910
Spike frequency adaptation has contributions from the IHERG current (encoded by the human eag-related gene (HERG); Warmke & Ganetzky, 1994), which develops with slow kinetics during depolarization and contributes to the repolarization of the long action potentials typically present in the heart. IHERG is one of the delayed rectifier currents (IK(r)) of the heart, and HERG mutations are associated with one of the cardiac arrhythmia LQT syndromes (LQT2). See paper for more and details.
Reference:
1 . Chiesa N, Rosati B, Arcangeli A, Olivotto M, Wanke E (1997) A novel role for HERG K+ channels: spike-frequency adaptation. J Physiol 501 ( Pt 2):313-8 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neuroblastoma;
Channel(s): I_HERG;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: XPP;
Model Concept(s): Action Potentials; Long-QT; Spike Frequency Adaptation;
Implementer(s): Wu, Sheng-Nan [snwu at mail.ncku.edu.tw]; Chang, Han-Dong; Wu, Jiun-Shian [coolneon at gmail.com];
Search NeuronDB for information about:  I_HERG;
/
kir_sim
readme.txt
kir_sim.ode
samplerun.jpg
                            
Loading data, please wait...