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Allosteric gating of K channels (Horrigan et al 1999)
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Calcium sensitive large-conductance K channel conductance is controlled by both cytoplasmic calcium and membrane potential. Experimental data obtained by the inside out patch method can be understood in terms of a gating scheme where a central transition between a closed and an open conformation is allosterically regulated by the state of four independent and identical voltage sensors. See paper for more and details.
Horrigan FT, Cui J, Aldrich RW (1999) Allosteric voltage gating of potassium channels I. Mslo ionic currents in the absence of Ca(2+).
J Gen Physiol
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Ion Channel Kinetics;
Wu, Sheng-Nan [snwu at mail.ncku.edu.tw];
Wu, Jiun-Shian [coolneon at gmail.com];
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