Allosteric gating of K channels (Horrigan et al 1999)

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Accession:58195
Calcium sensitive large-conductance K channel conductance is controlled by both cytoplasmic calcium and membrane potential. Experimental data obtained by the inside out patch method can be understood in terms of a gating scheme where a central transition between a closed and an open conformation is allosterically regulated by the state of four independent and identical voltage sensors. See paper for more and details.
Reference:
1 . Horrigan FT, Cui J, Aldrich RW (1999) Allosteric voltage gating of potassium channels I. Mslo ionic currents in the absence of Ca(2+). J Gen Physiol 114:277-304 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s): I K,Ca;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: XPP;
Model Concept(s): Ion Channel Kinetics; Methods;
Implementer(s): Wu, Sheng-Nan [snwu at mail.ncku.edu.tw]; Chang, Han-Dong; Wu, Jiun-Shian [coolneon at gmail.com];
Search NeuronDB for information about:  I K,Ca;
 
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ikca_horrigan_etal1999
                            
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