Role of KCNQ1 and IKs in cardiac repolarization (Silva, Rudy 2005) (XPP)

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Accession:58581
Detailed Markov model of IKs (the slow delayed rectifier K+ current) is supplied here in XPP. The model is compared to experiment in the paper. The role of IKs in disease and drug treatments is elucidated (the prevention of excessive action potential prolongation and development of arrhythmogenic early afterdepolarizations). See also modeldb accession number 55748 code and reference for more and details. This XPP version of the model reproduces Figure 3C in the paper by default. These model files were submitted by: Dr. Sheng-Nan Wu, Han-Dong Chang, Jiun-Shian Wu Department of Physiology National Cheng Kung University Medical College
Reference:
1 . Silva J, Rudy Y (2005) Subunit interaction determines IKs participation in cardiac repolarization and repolarization reserve. Circulation 112:1384-91 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s): I K; I Potassium; KCNQ1; I_Ks;
Gap Junctions:
Receptor(s):
Gene(s): Kv1.9 Kv7.1 KCNQ1;
Transmitter(s): Ions;
Simulation Environment: XPP;
Model Concept(s): Activity Patterns; Ion Channel Kinetics; Action Potentials; Heart disease; Long-QT;
Implementer(s): Wu, Sheng-Nan [snwu at mail.ncku.edu.tw]; Chang, Han-Dong; Wu, Jiun-Shian [coolneon at gmail.com];
Search NeuronDB for information about:  I K; I Potassium; KCNQ1; I_Ks; Ions;
  
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Silva J, Rudy Y (2005) Subunit interaction determines IKs participation in cardiac repolarization and repolarization reserve. Circulation 112:1384-91[PubMed]

References and models cited by this paper

References and models that cite this paper

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  • Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

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  • Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

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  • Ventricular cell model (Luo Rudy dynamic model) (Luo Rudy 1994) used in (Wang et al 2006) (XPP) [Model]
  • Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

(25 refs)