CA1 pyramidal neuron: conditional boosting of dendritic APs (Watanabe et al 2002)

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Accession:7386
Model files from the paper Watanabe S, Hoffman DA, Migliore M, Johnston D (2002). The experimental and modeling results support the hypothesis that dendritic K-A channels and the boosting of back-propagating action potentials contribute to the induction of LTP in CA1 neurons. See the paper for details. Questions about the model may be addressed to Michele Migliore: michele.migliore@pa.ibf.cnr.it
Reference:
1 . Watanabe S, Hoffman DA, Migliore M, Johnston D (2002) Dendritic K+ channels contribute to spike-timing dependent long-term potentiation in hippocampal pyramidal neurons. Proc Natl Acad Sci U S A 99:8366-8371 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal cell;
Channel(s): I Na,t; I A; I K;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Coincidence Detection; Active Dendrites; Detailed Neuronal Models; Action Potentials;
Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; AMPA; I Na,t; I A; I K;
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boosting
readme.txt
kadist.mod *
kaprox.mod *
kdrca1.mod *
na3.mod *
nax.mod *
fig6.hoc
mosinit.hoc
n160_mod.nrn *
                            
NEURON mod files from the paper:
S. Watanabe, D.A. Hoffman, M. Migliore, and D. Johnston
Dendritic K+ channels contribute to spike-timing dependent 
long-term potentiation in hippocampal pyramidal neurons 
Proc.Natl.Acad.Sci. USA 99:8366-8371, 2002.

The fig6.hoc simulation file will show the membrane potential
in a distal dendrite (350um from soma) for three simulations,
as in Fig.6 of the paper.
In each case two APs are elicited, unpaired with EPSPs
or paired with EPSPs after a 35 or 45ms delay.
The simulations show that the APs in the dendrites are boosted
only when they are paired with coincident EPSPs. 

Under unix systems:
to compile the mod files use the command 
nrnivmodl 
and run the simulation hoc file with the command 
nrngui fig6.hoc

Under Windows systems:
to compile the mod files use the "mknrndll" command.
A double click on the simulation file
fig6.hoc 
will open the simulation window.

Questions on how to use this model with NEURON
should be directed to michele.migliore@pa.ibf.cnr.it

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