CA1 Pyramidal Neuron: Synaptic Scaling (London, Segev 2001)


Help downloading and running models
Accession:7485
London and Segev (2001) discuss location dependent and location independent synaptic scaling in a model CA1 neuron with passive dendrites. The freely available text is followed by a critique by Maggee and Cook who comment that the London and Segev model is accurate and informative and however needs to be augmented by active channels in dendrites. Note: the zip files for this model are stored at the nature neuroscience website - Click above Supplementary Source Code in the readme.html in the model files
Reference:
1 . London M, Segev I (2001) Synaptic scaling in vitro and in vivo. Nat Neurosci 4:853-5 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal cell;
Channel(s):
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON (web link to model);
Model Concept(s): Activity Patterns; Simplified Models; Influence of Dendritic Geometry;
Implementer(s): London, Mickey [MikiLon at lobster.ls.huji.ac.il];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; AMPA;
(located via links below)
Loading data, please wait...