CA1 pyramidal neuron: Synaptic Scaling (Magee, Cook 2000)

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Accession:7509
Jeffrey Magee and Erik Cook found evidence in experiments and modeling that support the hypothesis that an increase in synaptic conductance for synapses at larger distances from the soma is responsible for reducing the location dependence (relative to the soma) of synapses.
Reference:
1 . Magee JC, Cook EP (2000) Somatic EPSP amplitude is independent of synapse location in hippocampal pyramidal neurons. Nat Neurosci 3:895-903 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal cell;
Channel(s):
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Influence of Dendritic Geometry;
Implementer(s): Magee, Jeffrey [jmagee at lsumc.edu];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; AMPA;
/
magee2000
readme.txt
ca1.nrn
main.hoc
main_example_epsps.hoc
mosinit.hoc
shape_plot.ses
                            
This collection of model files is associated with the paper:

Magee JC, Cook EP. Somatic EPSP amplitude is independent of synapse 
location in hippocampal pyramidal neurons. Nat Neurosci. 2000 Sep;3(9):895-903.

When auto-launched from ModelDB the program recreates fig4 a, b, c.

For more information about the model email Jeffrey Magee: jmagee@lsumc.edu
This model had minor modifications by Michael Hines and Tom Morse.

How to run the model (assuming that Neuron 5.2 or greater is installed)

PC platform:

	Download the zip file and extract its contents.
	Double click-on mosinit.hoc in Windows Explorer.

Unix platform:

	Download the zip file and extract its contents.
	cd to the directory that zip file created and type
	nrngui mosinit.hoc

MAC platform:

	Download the zip file.
	Drag and drop the zip file onto the mos2nrn icon.

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