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Dynamic dopamine modulation in the basal ganglia: Learning in Parkinson (Frank et al 2004,2005)
 
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Model Information
Model File
Citations
Accession:
79488
See README file for all info on how to run models under different tasks and simulated Parkinson's and medication conditions.
References:
1 .
Frank MJ (2005) Dynamic dopamine modulation in the basal ganglia: a neurocomputational account of cognitive deficits in medicated and nonmedicated Parkinsonism.
J Cogn Neurosci
17
:51-72
[
PubMed
]
2 .
Frank MJ, Seeberger LC, O'reilly RC (2004) By carrot or by stick: cognitive reinforcement learning in parkinsonism.
Science
306
:1940-3
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Realistic Network;
Brain Region(s)/Organism:
Basal ganglia;
Cell Type(s):
Neostriatum medium spiny direct pathway GABA cell;
Channel(s):
I Na,t;
I K,leak;
I Cl,Ca;
Gap Junctions:
Receptor(s):
D1;
D2;
Glutamate;
Gaba;
Gene(s):
Transmitter(s):
Dopamine;
Gaba;
Glutamate;
Simulation Environment:
Emergent/PDP++;
Model Concept(s):
Simplified Models;
Synaptic Plasticity;
Pathophysiology;
Rate-coding model neurons;
Parkinson's;
Reinforcement Learning;
Action Selection/Decision Making;
Hebbian plasticity;
Implementer(s):
Frank, Michael [mfrank at u.arizona.edu];
Search NeuronDB
for information about:
Neostriatum medium spiny direct pathway GABA cell
;
D1
;
D2
;
Glutamate
;
Gaba
;
I Na,t
;
I K,leak
;
I Cl,Ca
;
Dopamine
;
Gaba
;
Glutamate
;
Download the displayed file
/
BG_DA_Learn
supplement
README
analpr.sh
analrf.sh
analRF_ab_gonogo.css
analwp_seq.css
analwp_trn.sh
analwp_tst.sh
BG_DA_model_STN_2str_GoNoGoRF.proj.gz
BG_DA_model_STN_2str_ProbReversal_repl.proj.gz
BG_DA_model_STN_2str_WeatherPred_repl.proj.gz
DAcontrast.css
Dopamine_Rew_Punish_nothr_2str_4mtr.css
Dopamine_Rew_Punish_nothr_2str_4mtr_nodip.css
Dopamine_Rew_Punish_nothr_2str_4mtr_pd.css
meds_run.css
normal_run.css
pd.css
pd_run.css
PR_intact_repl.log
PR_intact_repl.log.dt
PR_meds_repl.log
PR_meds_repl.log.dt
PS_intact_repl.log
PS_intact_repl.log.dt
PS_meds_repl.log
PS_meds_repl.log.dt
PS_PD_repl.log
PS_PD_repl.log.dt
WP_intact_repl.log
WP_intact_repl.log.dt
WP_intact_repl.log.dt.dt
WP_intact_trn.log
WP_PD_repl.log
WP_PD_repl.log.dt
WP_PD_repl.log.dt.dt
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