Dynamic dopamine modulation in the basal ganglia: Learning in Parkinson (Frank et al 2004,2005)

 Download zip file 
Help downloading and running models
Accession:79488
See README file for all info on how to run models under different tasks and simulated Parkinson's and medication conditions.
References:
1 . Frank MJ (2005) Dynamic dopamine modulation in the basal ganglia: a neurocomputational account of cognitive deficits in medicated and nonmedicated Parkinsonism. J Cogn Neurosci 17:51-72 [PubMed]
2 . Frank MJ, Seeberger LC, O'reilly RC (2004) By carrot or by stick: cognitive reinforcement learning in parkinsonism. Science 306:1940-3 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Basal ganglia;
Cell Type(s): Neostriatum medium spiny direct pathway neuron;
Channel(s): I Na,t; I K,leak; I Cl,Ca;
Gap Junctions:
Receptor(s): D1; D2; Glutamate; Gaba;
Gene(s):
Transmitter(s): Dopamine; Gaba; Glutamate;
Simulation Environment: Emergent/PDP++;
Model Concept(s): Simplified Models; Synaptic Plasticity; Pathophysiology; Rate-coding model neurons; Parkinson's; Reinforcement Learning; Action Selection/Decision Making; Hebbian plasticity;
Implementer(s): Frank, Michael [mfrank at u.arizona.edu];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway neuron; D1; D2; Glutamate; Gaba; I Na,t; I K,leak; I Cl,Ca; Dopamine; Gaba; Glutamate;
Loading data, please wait...