Dynamic dopamine modulation in the basal ganglia: Learning in Parkinson (Frank et al 2004,2005)

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Accession:79488
See README file for all info on how to run models under different tasks and simulated Parkinson's and medication conditions.
References:
1 . Frank MJ (2005) Dynamic dopamine modulation in the basal ganglia: a neurocomputational account of cognitive deficits in medicated and nonmedicated Parkinsonism. J Cogn Neurosci 17:51-72 [PubMed]
2 . Frank MJ, Seeberger LC, O'reilly RC (2004) By carrot or by stick: cognitive reinforcement learning in parkinsonism. Science 306:1940-3 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Basal ganglia;
Cell Type(s): Neostriatum medium spiny direct pathway neuron;
Channel(s): I Na,t; I K,leak; I Cl,Ca;
Gap Junctions:
Receptor(s): D1; D2; Glutamate; Gaba;
Gene(s):
Transmitter(s): Dopamine; Gaba; Glutamate;
Simulation Environment: Emergent/PDP++;
Model Concept(s): Simplified Models; Synaptic Plasticity; Pathophysiology; Rate-coding model neurons; Parkinson's; Reinforcement Learning; Action Selection/Decision Making; Hebbian plasticity;
Implementer(s): Frank, Michael [mfrank at u.arizona.edu];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway neuron; D1; D2; Glutamate; Gaba; I Na,t; I K,leak; I Cl,Ca; Dopamine; Gaba; Glutamate;
      1	     50	   0.76	  0.101	
      2	     50	   0.82	  0.113	
      3	     50	   0.86	  0.103	
      4	     50	   0.72	 0.0949	
      5	     50	   0.54	 0.0957	
      6	     50	   0.56	 0.0954	
      7	     50	   0.56	 0.0954	
      8	     50	   0.42	 0.0861	
      9	     50	   0.38	 0.0803	
     10	     50	   0.42	 0.0861	
     11	     50	   0.44	 0.0816	
     12	     50	   0.32	 0.0878	
     13	     50	   0.42	 0.0908	
     14	     50	    0.4	 0.0857	
     15	     50	   0.52	 0.0958	
     16	     50	   0.46	 0.0819	
     17	     50	    0.3	 0.0714	
     18	     50	   0.28	 0.0702	
     19	     50	    0.3	 0.0769	
     20	     50	   1.56	 0.0911	
     21	     50	   1.26	 0.0982	
     22	     50	   0.92	   0.11	
     23	     50	   0.88	  0.113	
     24	     50	   0.76	  0.105	
     25	     50	   0.66	  0.105	
     26	     50	   0.58	 0.0908	
     27	     50	   0.56	 0.0911	
     28	     50	    0.6	 0.0948	
     29	     50	   0.58	 0.0951	
     30	     50	   0.62	  0.103	
     31	     50	   0.64	   0.11	
     32	     50	   0.52	 0.0914	
     33	     50	   0.64	  0.098	
     34	     50	   0.48	 0.0958	
     35	     50	    0.5	 0.0915	
     36	     50	   0.58	 0.0951	
     37	     50	   0.46	 0.0913	
     38	     50	   0.58	  0.103	
     39	     50	    0.7	    0.1	
     40	    100	   0.65	 0.0642	

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