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Dynamic dopamine modulation in the basal ganglia: Learning in Parkinson (Frank et al 2004,2005)
 
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Model Information
Model File
Citations
Accession:
79488
See README file for all info on how to run models under different tasks and simulated Parkinson's and medication conditions.
References:
1 .
Frank MJ (2005) Dynamic dopamine modulation in the basal ganglia: a neurocomputational account of cognitive deficits in medicated and nonmedicated Parkinsonism.
J Cogn Neurosci
17
:51-72
[
PubMed
]
2 .
Frank MJ, Seeberger LC, O'reilly RC (2004) By carrot or by stick: cognitive reinforcement learning in parkinsonism.
Science
306
:1940-3
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Realistic Network;
Brain Region(s)/Organism:
Basal ganglia;
Cell Type(s):
Neostriatum medium spiny direct pathway GABA cell;
Channel(s):
I Na,t;
I K,leak;
I Cl,Ca;
Gap Junctions:
Receptor(s):
D1;
D2;
Glutamate;
Gaba;
Gene(s):
Transmitter(s):
Dopamine;
Gaba;
Glutamate;
Simulation Environment:
Emergent/PDP++;
Model Concept(s):
Simplified Models;
Synaptic Plasticity;
Pathophysiology;
Rate-coding model neurons;
Parkinson's;
Reinforcement Learning;
Action Selection/Decision Making;
Hebbian plasticity;
Implementer(s):
Frank, Michael [mfrank at u.arizona.edu];
Search NeuronDB
for information about:
Neostriatum medium spiny direct pathway GABA cell
;
D1
;
D2
;
Glutamate
;
Gaba
;
I Na,t
;
I K,leak
;
I Cl,Ca
;
Dopamine
;
Gaba
;
Glutamate
;
/
BG_DA_Learn
supplement
BG_ProbRev.proj
BG_ProbSelect.proj
BG_WeatherPred.proj
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