ModelDB: Dynamic dopamine modulation in the basal ganglia: Learning in Parkinson (Frank et al 2004,2005)

Dynamic dopamine modulation in the basal ganglia: Learning in Parkinson (Frank et al 2004,2005)

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Model Information
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Citations

Accession:79488

See README file for all info on how to run models under different tasks and simulated Parkinson's and medication conditions.
References:
1 . Frank MJ (2005) Dynamic dopamine modulation in the basal ganglia: a neurocomputational account of cognitive deficits in medicated and nonmedicated Parkinsonism. J Cogn Neurosci 17:51-72 [PubMed]
2 . Frank MJ, Seeberger LC, O'reilly RC (2004) By carrot or by stick: cognitive reinforcement learning in parkinsonism. Science 306:1940-3 [PubMed]

Model Information (Click on a link to find other models with that property)

Model Type:	Realistic Network;
Brain Region(s)/Organism:	Basal ganglia;
Cell Type(s):	Neostriatum medium spiny direct pathway neuron;
Channel(s):	I Na,t; I K,leak; I Cl,Ca;
Gap Junctions:
Receptor(s):	D1; D2; Glutamate; Gaba;
Gene(s):
Transmitter(s):	Dopamine; Gaba; Glutamate;
Simulation Environment:	Emergent/PDP++;
Model Concept(s):	Simplified Models; Synaptic Plasticity; Pathophysiology; Rate-coding model neurons; Parkinson's; Reinforcement Learning; Action Selection/Decision Making; Hebbian plasticity;
Implementer(s):	Frank, Michael [mfrank at u.arizona.edu];

Search NeuronDB for information about: Neostriatum medium spiny direct pathway neuron; D1; D2; Glutamate; Gaba; I Na,t; I K,leak; I Cl,Ca; Dopamine; Gaba; Glutamate;

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