Ih levels roles in bursting and regular-spiking subiculum pyramidal neurons (van Welie et al 2006)

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Accession:82364
Pyramidal neurons in the subiculum typically display either bursting or regular-spiking behavior. ... Here we report that bursting neurons posses a hyperpolarization-activated cation current (Ih) that is two-fold larger (conductance: 5.3 ± 0.5 nS) than in regularspiking neurons (2.2 ± 0.6 nS), while Ih exhibits similar voltage-dependent and kinetic properties in both classes of neurons. Bursting and regular-spiking neurons display similar morphology. The difference in Ih between the two classes is not responsible for the distinct firing patterns, since neither pharmacological blockade of Ih nor enhancement of Ih using a dynamic clamp affects the qualitative firing patterns. Instead, the difference in Ih between bursting and regular-spiking neurons determines the temporal integration of evoked synaptic input from the CA1 area. In response to 50 Hz stimulation, bursting neurons, with a large Ih, show ~50% less temporal summation than regular-spiking neurons. ... A computer simulation model of a subicular neuron with the properties of either a bursting or a regular-spiking neuron confirmed the pivotal role of Ih in temporal integration of synaptic input. These data suggest that in the subicular network, bursting neurons are better suited to discriminate the content of high frequency input, such as that occurring during gamma oscillations, compared to regular-spiking neurons. See paper for more and details.
Reference:
1 . van Welie I, Remme MW, van Hooft JA, Wadman WJ (2006) Different levels of Ih determine distinct temporal integration in bursting and regular-spiking neurons in rat subiculum. J Physiol 576:203-214 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s): I h;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Coincidence Detection; Synaptic Integration;
Implementer(s):
Search NeuronDB for information about:  AMPA; I h;
NEURON files from the paper:

Ingrid van Welie, Michiel W.H. Remme, Johannes A. van Hooft, and Wytse
J. Wadman Different levels of Ih determine distinct temporal
integration in bursting and regular-spiking neurons in rat subiculum,
Journal of Physiology (2006). DOI:10.1113/jphysiol.2006.1139441

The subiculum.hoc file will run four 800ms simulations plotting the
membrane potential at the soma

The cell morphology is the one illustrated in figure 6A (now with the
axon).  The morphology of this typical subiculum neuron is given in
the S40.hoc file

The simulation produces part of the data illustrated in figure 6D and
6E.

Regular and burst firing pyramidal neurons from the subiculum differ
in the levels of Ih. In the simulations a fraction of the AMPA
synapses distributed over the apical dendrites are simultaneously
activated at eiter 20 Hz or 50 Hz in both types of neurons. The
simulations support the experimental results from the paper,
illustrating that the different densities of Ih affect the summation
of the synaptic input when recorded from the soma.

Under unix systems:
to compile the mod files use the command 
nrnivmodl 
and run the simulation hoc file with the command 
nrngui subiculum.hoc

Under Windows systems:
to compile the mod files use the "mknrndll" command.
A double click on the simulation file
subiculum.hoc 
will open the simulation window.

Questions on how to use this model should be directed to
wadman@science.uva.nl

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