Spiking neuron model of the basal ganglia (Humphries et al 2006)

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Accession:83559
A spiking neuron model of the basal ganglia (BG) circuit (striatum, STN, GP, SNr). Includes: parallel anatomical channels; tonic dopamine; dopamine receptors in striatum, STN, and GP; burst-firing in STN; GABAa, AMPA, and NMDA currents; effects of synaptic location. Model demonstrates selection and switching of input signals. Replicates experimental data on changes in slow-wave (<1 Hz) and gamma-band oscillations within BG nuclei following lesions and pharmacological manipulations.
Reference:
1 . Humphries MD, Stewart RD, Gurney KN (2006) A physiologically plausible model of action selection and oscillatory activity in the basal ganglia. J Neurosci 26:12921-42 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Basal ganglia;
Cell Type(s): Neostriatum medium spiny direct pathway neuron; Subthalamus nucleus projection neuron; Globus pallidus neuron; Abstract integrate-and-fire leaky neuron;
Channel(s):
Gap Junctions:
Receptor(s): Dopaminergic Receptor;
Gene(s):
Transmitter(s): Dopamine; Gaba; Glutamate;
Simulation Environment: MATLAB;
Model Concept(s): Oscillations; Parkinson's; Action Selection/Decision Making; Sleep; Rebound firing;
Implementer(s): Humphries, Mark D [m.d.humphries at shef.ac.uk];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway neuron; Dopaminergic Receptor; Dopamine; Gaba; Glutamate;
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do_raster = 0;
do_means = 1;
do_trace = 0;
do_isi = 0;
do_bursts = 1;
do_spectra = 1;
do_coherence = 0;
do_xcorr_intra = 0;
do_xcorr_inter = 0;
do_total_xcorr_stats = 0;       % compute confidence intervals for total xcorr - can take a long time if firing rates are high
do_acorr = 1;
do_spike_trig_avg = 1;

save_full_analysis = 1;
save_summary_analysis = 0;

do_display = 0;

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