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Modeling temperature changes in AMPAR kinetics (Postlethwaite et al 2007)
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This model was used to simulate glutamatergic, AMPA receptor mediated mEPSCs (miniature EPSCs, resulting from spontaneous vesicular transmitter release) at the calyx of Held synapse. It was used to assess the influence of temperature (physiological vs. subphysiological) on the amplitude and time course of mEPSCs. In the related paper, simulation results were directly compared to the experimental data, and it was concluded that an increase of temperature accelerates AMPA receptor kinetics.
Postlethwaite M, Hennig MH, Steinert JR, Graham BP, Forsythe ID (2007) Acceleration of AMPA receptor kinetics underlies temperature-dependent changes in synaptic strength at the rat calyx of Held.
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Neuron or other electrically excitable cell;
Medial Nucleus of the Trapezoid Body (MNTB) neuron;
Detailed Neuronal Models;
Short-term Synaptic Plasticity;
Hennig, Matthias H [mhhennig at gmail.com];
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Other models using effectors.mdl:
Analytical modelling of temperature effects on an AMPA-type synapse (Kufel & Wojcik 2018)
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