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TTX-R Na+ current effect on cell response (Herzog et al 2001)
 
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Model Information
Model File
Citations
Accession:
86537
"Small dorsal root ganglion (DRG) neurons, which include nociceptors, express multiple voltage-gated sodium currents. In addition to a classical fast inactivating tetrodotoxin-sensitive (TTX-S) sodium current, many of these cells express a TTX-resistant (TTX-R) sodium current that activates near -70 mV and is persistent at negative potentials. To investigate the possible contributions of this TTX-R persistent (TTX-RP) current to neuronal excitability, we carried out computer simulations using the Neuron program with TTX-S and -RP currents, fit by the Hodgkin-Huxley model, that closely matched the currents recorded from small DRG neurons. ..." See paper for more and details.
Reference:
1 .
Herzog RI, Cummins TR, Waxman SG (2001) Persistent TTX-resistant Na+ current affects resting potential and response to depolarization in simulated spinal sensory neurons.
J Neurophysiol
86
:1351-64
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Dorsal Root Ganglion (DRG) cell;
Channel(s):
I Na,p;
I Na,t;
I K;
Gap Junctions:
Receptor(s):
Gene(s):
Nav1.1 SCN1A;
Nav1.6 SCN8A;
Nav1.7 SCN9A;
Nav1.8 SCN10A;
Nav1.9 SCN11A SCN12A;
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Ion Channel Kinetics;
Nociception;
Implementer(s):
Morse, Tom [Tom.Morse at Yale.edu];
Search NeuronDB
for information about:
I Na,p
;
I Na,t
;
I K
;
/
herzogEtAl01
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