Model of calcium oscillations in olfactory cilia (Reidl et al. 2006)

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Simulation of experiments on olfactory receptor neurons (ORNs). Focussing on the negative feedback that calcium (through calmodulin) has on its own influx through CNG channels, this model is able to reproduce both calcium oscillations as well as adaptation behaviour as seen in experiments done with ORNs.
1 . Reidl J, Borowski P, Sensse A, Starke J, Zapotocky M, Eiswirth M (2006) Model of calcium oscillations due to negative feedback in olfactory cilia. Biophys J 90:1147-55 [PubMed]
2 . Borowski P (2006) Stochastic dynamics in olfactory signal transduction and development, Dissertation
Model Information (Click on a link to find other models with that property)
Model Type: Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Olfactory receptor neuron;
Channel(s): I CNG;
Gap Junctions:
Simulation Environment: MATLAB;
Model Concept(s): Activity Patterns; Ion Channel Kinetics; Temporal Pattern Generation; Oscillations; Simplified Models; Signaling pathways; Calcium dynamics;
Search NeuronDB for information about:  Olfactory receptor neuron; I CNG;
This is the readme file for the model "Model of calcium oscillations
in olfactory cilia (Reidl et al. 2006)", which is the matlab program

To run the matlab program, download it and start matlab. Within
matlab, change to the directory that contains the program. Type at the
matlab prompt


with q= 2,3 or 4 (see the comments in the program code for the


1) J.Reidl, P.Borowski, A.Sensse, J.Starke, M.Zapotocky and
M.Eiswirth, "Model of Calcium Oscillations Due to Negative Feedback in
Olfactory Cilia", Biophys.J. 90, 1147 (2006)

2) P.Borowski, "Stochastic dynamics in olfactory signal transduction
and development", Dissertation (2006):

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