STDP and NMDAR Subunits (Gerkin et al. 2007)

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Accession:87216
The paper argues for competing roles of NR2A- and NR2B-containing NMDARs in spike-timing-dependent plasticity. This simple dynamical model recapitulates the results of STDP experiments involving selective blockers of NR2A- and NR2B-containing NMDARs, for which the stimuli are pre- and postsynaptic spikes in varying combinations. Experiments were done using paired recordings from glutamatergic neurons in rat hippocampal cultures. This model focuses on the dynamics of the putative potentiation and depression modules themselves, and their interaction For detailed dynamics involving NMDARs and Ca2+ transients, see Rubin et al., J. Neurophys., 2005.
Reference:
1 . Gerkin RC, Lau PM, Nauen DW, Wang YT, Bi GQ (2007) Modular competition driven by NMDA receptor subtypes in spike-timing-dependent plasticity. J Neurophysiol 97:2851-62 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal cell; Hippocampus CA3 pyramidal cell;
Channel(s):
Gap Junctions:
Receptor(s): NMDA;
Gene(s): NR2A GRIN2A; NR2B GRIN2B;
Transmitter(s):
Simulation Environment: IGOR Pro;
Model Concept(s): Activity Patterns; Synaptic Plasticity; Long-term Synaptic Plasticity; Signaling pathways; Synaptic Integration; Winner-take-all; STDP;
Implementer(s):
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; Hippocampus CA3 pyramidal cell; NMDA;
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gerkinetal2007
readme.txt
code.txt
Gerkin_JNeurophys_2007.pxp
Instructions.rtf
                            
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