Slow wave propagation in the guinea-pig gastric antrum (Hirst et al. 2006, Edwards and Hirst 2006)

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"(Edwards and Hirst 2006) provides an electrical description of the propagation of slow waves and pacemaker potentials in the guinea-pig gastric antrum in anal and circumferential directions. As electrical conduction between laterally adjacent circular muscle bundles is regularly interrupted, anal conduction of pacemaker potentials was assumed to occur via an electrically interconnected chain of myenteric interstitial cells of Cajal (ICCMY). ICCMY were also connected resistively to serially connected compartments of longitudinal muscle. Circumferential conduction occurred in a circular smooth muscle bundle that was represented as a chain of electrically connected isopotential compartments: each compartment contained a proportion of intramuscular interstitial cells of Cajal (ICCIM) that are responsible for the regenerative component of the slow wave. The circular muscle layer, which contains ICCIM, and the ICCMY network incorporated a mechanism, modelled as a two-stage chemical reaction, which produces an intracellular messenger. ... The model generates pacemaker potentials and slow waves with propagation velocities similar to those determined in the physiological experiments described in the accompanying paper."
1 . Edwards FR, Hirst GD (2006) An electrical analysis of slow wave propagation in the guinea-pig gastric antrum. J Physiol 571:179-89 [PubMed]
2 . Hirst GD, Garcia-LondoƱo AP, Edwards FR (2006) Propagation of slow waves in the guinea-pig gastric antrum. J Physiol 571:165-77 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Enteric nervous system;
Cell Type(s): Myenteric interstitial cell of Cajal (ICCMY); Intramuscular interstitial cell of Cajal (ICCIM);
Gap Junctions:
Simulation Environment: MATLAB;
Model Concept(s): Temporal Pattern Generation; Oscillations; Spatio-temporal Activity Patterns;
Implementer(s): Edwards, Frank [frank.edwards at];
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