Olfactory bulb mitral and granule cell: dendrodendritic microcircuits (Migliore and Shepherd 2008)

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Accession:97263
This model shows how backpropagating action potentials in the long lateral dendrites of mitral cells, together with granule cell actions on mitral cells within narrow columns forming glomerular units, can provide a mechanism to activate strong local inhibition between arbitrarily distant mitral cells. The simulations predict a new role for the dendrodendritic synapses in the multicolumnar organization of the granule cells.
Reference:
1 . Migliore M, Shepherd GM (2008) Dendritic action potentials connect distributed dendrodendritic microcircuits J Comp Neurosci 24(2):207-221 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Olfactory bulb;
Cell Type(s): Olfactory bulb main mitral cell; Olfactory bulb main interneuron granule MC cell;
Channel(s): I Na,t; I A; I K;
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Pattern Recognition; Activity Patterns; Dendritic Action Potentials; Active Dendrites; Detailed Neuronal Models; Action Potentials; Olfaction;
Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu];
Search NeuronDB for information about:  Olfactory bulb main mitral cell; Olfactory bulb main interneuron granule MC cell; AMPA; NMDA; I Na,t; I A; I K; Gaba; Glutamate;
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MT-GC
readme.txt *
kamt.mod *
kdrmt.mod *
naxn.mod *
nmdanetOB.mod *
coeff-table.txt *
forfig3.hoc *
gc.hoc *
mitral.hoc *
mosinit.hoc *
                            
NEURON mod files from the paper:

Michele Migliore and Gordon M Shepherd
Dendritic action potentials connect distributed dendrodendritic microcircuits
J. Comp. Neurosci. (2007) (online first).

The simulation file can be used to reproduce the bottom left histogram
in Fig.3,representing the M2 mitral cell firing in the presence of the
GCs network.  In the simulation window, "odor" is the number of odor
input (3-11), and traces for the 3 Mitral cells are plotted using
different colors.

To start, auto-launch from ModelDB or

Under unix systems:
to compile the mod files use the command 
nrnivmodl 
and run the simulation hoc file with the command 
nrngui mosinit.hoc

Under Windows systems:

to compile the mod files use the "mknrndll" program on the folder
expanded from this archive, then double click on the simulation file
mosinit.hoc to start the simulation.

Under MAC OS X:

Expand the MC-GC.zip archive after downloading it.  Drag the MC-GC
folder onto the mknrndll icon in the NEURON application folder.  Drag
the mosinit.hoc file in the MC-GC folder onto the nrngui icon in the
NEURON application folder.

For each platform:

Enter the odor number next to the odor button, press Run, and count
the number of M2 APs (red trace).  Repeat for odors 3 through 11.

Questions on how to use this model
should be directed to michele.migliore@pa.ibf.cnr.it

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