Model of DARPP-32 phosphorylation in striatal medium spiny neurons (Lindskog et al. 2006)

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Accession:97743
The work describes a model of how transient calcium and dopamine inputs might affect phosphorylation of DARPP-32 in the medium spiny neurons in the striatum. The model is relevant for understanding both the "three-factor rule" for synaptic plasticity in corticostriatal synapses, and also for relating reinforcement learning theories to biology.
Reference:
1 . Lindskog M, Kim M, Wikstrom MA, Blackwell KT, Kotaleski JH (2006) Transient calcium and dopamine increase PKA activity and DARPP-32 phosphorylation. PLoS Comput Biol 2:e119 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Molecular Network;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum spiny direct pathway neuron;
Channel(s): I Calcium;
Gap Junctions:
Receptor(s): D1; D2;
Gene(s): D1 DRD1A; D2 DRD2;
Transmitter(s): Dopamine;
Simulation Environment: XPP;
Model Concept(s): Long-term Synaptic Plasticity; Signaling pathways; Reinforcement Learning;
Implementer(s):
Search NeuronDB for information about:  Neostriatum spiny direct pathway neuron; D1; D2; I Calcium; Dopamine;
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DARPPmodel_2006
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DARPPmodel_2006.ode
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