Mammalian Ventricular Cell (Beeler and Reuter 1977)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:97863
This classic model of ventricular myocardial fibres was implemented by Francois Gannier. "... Four individual components of ionic current were formulated mathematically in terms of Hodgkin-Huxley type equations. The model incorporates two voltage- and time-dependent inward currents, the excitatory inward sodium current, illa, and a secondary or slow inward current, is, primarily carried by calcium ions. A time-independent outward potassium current, iK1, exhibiting inward-going rectification, and a voltage- and time-dependent outward current, i.1, primarily carried by potassium ions, are further elements of the model...."
Reference:
1 . Beeler GW, Reuter H (1977) Reconstruction of the action potential of ventricular myocardial fibres. J Physiol 268:177-210 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Cardiac ventricular cell;
Channel(s): I K; I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Ion Channel Kinetics; Action Potentials;
Implementer(s): Gannier, Francois [francois.gannier at univ-tours.fr];
Search NeuronDB for information about:  I K; I Sodium; I Calcium; I Potassium;
TITLE intracellular Calcium concentration dynamic
: from BEELER & REUTER, J.Physiol, 1977

COMMENT
	 Cardiac intracellular calcium 
ENDCOMMENT

NEURON {
	SUFFIX Cadynam
	USEION ca READ ica, cai WRITE cai
	USEION cs READ ics VALENCE 2
	RANGE ics
}

UNITS {
	(mM) = (milli/liter)
	(mA) = (milliamp)
}

ASSIGNED{
	ica		(mA/cm2)
	ics		(mA/cm2)
}

PARAMETER {
}

STATE {
	cai START 0.001 (mM)  <1e-6>
}

INITIAL {
	VERBATIM
		cai = _ion_cai;
	ENDVERBATIM
}

BREAKPOINT {
	SOLVE state METHOD derivimplicit
}

DERIVATIVE state { 
	cai' = -1e-7*ics+0.07*(1e-7-cai)
}

Loading data, please wait...