Mammalian Ventricular Cell (Beeler and Reuter 1977)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:97863
This classic model of ventricular myocardial fibres was implemented by Francois Gannier. "... Four individual components of ionic current were formulated mathematically in terms of Hodgkin-Huxley type equations. The model incorporates two voltage- and time-dependent inward currents, the excitatory inward sodium current, illa, and a secondary or slow inward current, is, primarily carried by calcium ions. A time-independent outward potassium current, iK1, exhibiting inward-going rectification, and a voltage- and time-dependent outward current, i.1, primarily carried by potassium ions, are further elements of the model...."
Reference:
1 . Beeler GW, Reuter H (1977) Reconstruction of the action potential of ventricular myocardial fibres. J Physiol 268:177-210 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Cardiac ventricular cell;
Channel(s): I K; I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Ion Channel Kinetics; Action Potentials;
Implementer(s): Gannier, Francois [francois.gannier at univ-tours.fr];
Search NeuronDB for information about:  I K; I Sodium; I Calcium; I Potassium;
load_file("nrngui.hoc")
create soma
access soma

celsius = 37
tstop = 50000
{diam=16  L=100 nseg=1} 

load_file("init.ses")
//load_file("ramp.ses")

cai = 1.02e-4
cao = 1.8  
nai = 11
nao = 140
ko = 5.4 

Loading data, please wait...