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Determinants of fast calcium dynamics in dendritic spines and dendrites (Cornelisse et al. 2007)
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"... Calcium influx time course and calcium extrusion rate were both in the same range for spines and dendrites when fitted with a dynamic multi-compartment model that included calcium binding kinetics and diffusion. In a subsequent analysis we used this model to investigate which parameters are critical determinants in spine calcium dynamics. The model confirmed the experimental findings: a higher SVR (surface-to-volume ratio) is not sufficient by itself to explain the faster rise time kinetics in spines, but only when paired with a lower buffer capacity in spines. Simulations at zero calcium-dye conditions show that calmodulin is more efficiently activated in spines, which indicates that spine morphology and buffering conditions in neocortical spines favor synaptic plasticity. ..."
Cornelisse LN, van Elburg RAJ, Meredith RM, Yuste R, Mansvelder HD (2007) High Speed Two-Photon Imaging of Calcium Dynamics in Dendritic Spines: Consequences for Spine Calcium Kinetics and Buffer Capacity.
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Neocortex U1 pyramidal intratelencephalic L2-6 cell;
CalC Calcium Calculator;
van Elburg, Ronald A.J. [R.van.Elburg at ai.rug.nl];
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Neocortex U1 pyramidal intratelencephalic L2-6 cell
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