D2 dopamine receptor modulation of interneuronal activity (Maurice et al. 2004)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:98005
"... Using a combination of electrophysiological, molecular, and computational approaches, the studies reported here show that D2 dopamine receptor modulation of Na+ currents underlying autonomous spiking contributes to a slowing of discharge rate, such as that seen in vivo. Four lines of evidence support this conclusion. ... Fourth, simulation of cholinergic interneuron pacemaking revealed that a modest increase in the entry of Na+ channels into the slow-inactivated state was sufficient to account for the slowing of pacemaker discharge. These studies establish a cellular mechanism linking dopamine and the reduction in striatal cholinergic interneuron activity seen in the initial stages of associative learning." See paper for more and details.
Reference:
1 . Maurice N, Mercer J, Chan CS, Hernandez-Lopez S, Held J, Tkatch T, Surmeier DJ (2004) D2 dopamine receptor-mediated modulation of voltage-dependent Na+ channels reduces autonomous activity in striatal cholinergic interneurons. J Neurosci 24:10289-301 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum interneuron ACh cell;
Channel(s): I Na,t; I K; I h; I K,Ca; I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s): D2;
Gene(s): D2 DRD2; HCN1; HCN2;
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Action Potentials; Parkinson's;
Implementer(s): Held, Joshua [j-held at northwestern.edu];
Search NeuronDB for information about:  Neostriatum interneuron ACh cell; D2; I Na,t; I K; I h; I K,Ca; I Sodium; I Calcium; I Potassium;
// Cholinergic Interneuron
//
// Josh Held, 7/2004

load_file("nrngui.hoc")

create soma, dend[2]

connect dend[0](0), soma(0)
connect dend[1](0), soma(1)

access soma

celsius = 22
forall Ra = 70
v_init = -55

soma {
	L = 20
	diam = 20
	
	insert pas
		g_pas = .001
		e_pas = -55
	insert na_ch
		gbar_na_ch = 0.4
	insert na2_ch
		gbar_na2_ch = 1
	insert kv2_ch
		gbar_kv2_ch = .1
	insert kv4_ch
		gbar_kv4_ch = .4
	insert kcnq_ch
		gbar_kcnq_ch = .002
	insert kir2_ch
		gbar_kir2_ch = 0
	insert bk_ch
		gbar_bk_ch = 1
	insert sk_ch
		gbar_sk_ch = .003
	insert hcn12_ch
		gbar_hcn12_ch = 0
	insert hcn2_ch
		gbar_hcn2_ch = 0
	insert cal_ch
		gbar_cal_ch = .003
	insert cap_ch
		gbar_cap_ch = 5e-05
	insert ca_ch	// calcium handling
}

for i=0,1 {
	dend[i] {
		L  = 200
		diam = 2
	
		insert pas
			g_pas = .001
			e_pas = -55
		insert na_ch
			gbar_na_ch = 0.1
		insert na2_ch
			gbar_na2_ch = 0.25
		insert kv2_ch
			gbar_kv2_ch = .1
		insert kv4_ch
			gbar_kv4_ch = .4
		insert kcnq_ch
			gbar_kcnq_ch = .0003
		insert kir2_ch
			gbar_kir2_ch = 0
		insert bk_ch
			gbar_bk_ch = 1
		insert sk_ch
			gbar_sk_ch = .003
		insert hcn12_ch
			gbar_hcn12_ch = .01
		insert hcn2_ch
			gbar_hcn2_ch = .03
		insert cal_ch
			gbar_cal_ch = .003
		insert cap_ch
			gbar_cap_ch = 0
		insert ca_ch	// calcium handling
	}
}

load_file("graph.hoc")
load_file("changeval.hoc")

// A RunControl panel
xpanel("RunControl", 0)
	v_init = -55
	xvalue("Init","v_init", 1,"stdinit()", 1, 1 )
	xbutton("Init & Run","run()")
	xbutton("Stop","stoprun=1")
	runStopAt = 5
	xvalue("Continue til","runStopAt", 1,"{continuerun(runStopAt) stoprun=1}", 1, 1 )
	runStopIn = 1
	xvalue("Continue for","runStopIn", 1,"{continuerun(t + runStopIn) stoprun=1}", 1, 1 )
	xbutton("Single Step","steprun()")
	t = 0
	xvalue("t","t", 2 )
	tstop = 5000
	xvalue("Tstop","tstop", 1,"tstop_changed()", 0, 1 )
	dt = 0.25
	xvalue("dt","dt", 1,"setdt()", 0, 1 )
	steps_per_ms = 4
	xvalue("Points plotted/ms","steps_per_ms", 1,"setdt()", 0, 1 )
	xcheckbox("Quiet",&stdrun_quiet,"")
	realtime = 0
	xvalue("Real Time","realtime", 0,"", 0, 1 )
xpanel(0,400)

Loading data, please wait...