D2 dopamine receptor modulation of interneuronal activity (Maurice et al. 2004)

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Accession:98005
"... Using a combination of electrophysiological, molecular, and computational approaches, the studies reported here show that D2 dopamine receptor modulation of Na+ currents underlying autonomous spiking contributes to a slowing of discharge rate, such as that seen in vivo. Four lines of evidence support this conclusion. ... Fourth, simulation of cholinergic interneuron pacemaking revealed that a modest increase in the entry of Na+ channels into the slow-inactivated state was sufficient to account for the slowing of pacemaker discharge. These studies establish a cellular mechanism linking dopamine and the reduction in striatal cholinergic interneuron activity seen in the initial stages of associative learning." See paper for more and details.
Reference:
1 . Maurice N, Mercer J, Chan CS, Hernandez-Lopez S, Held J, Tkatch T, Surmeier DJ (2004) D2 dopamine receptor-mediated modulation of voltage-dependent Na+ channels reduces autonomous activity in striatal cholinergic interneurons. J Neurosci 24:10289-301 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum interneuron ACh cell;
Channel(s): I Na,t; I K; I h; I K,Ca; I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s): D2;
Gene(s): D2 DRD2; HCN1; HCN2;
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Action Potentials; Parkinson's;
Implementer(s): Held, Joshua [j-held at northwestern.edu];
Search NeuronDB for information about:  Neostriatum interneuron ACh cell; D2; I Na,t; I K; I h; I K,Ca; I Sodium; I Calcium; I Potassium;
TITLE KCNQ/M current from striatal medium spiny neurons, used for ch. interneuron.

:KCNQ_CH.MOD
:
: 11/3/2003

NEURON {
        SUFFIX kcnq_ch
        USEION k READ ek WRITE ik
        RANGE ik, ek, g, gbar
        GLOBAL a0, b0, ah, bh, ac, bc
}

UNITS {
        (mV) = (millivolt)
	(mA) = (milliamp)
	(S) = (siemens)
}

PARAMETER {
        gbar    = 1		(S/cm2)
        ek			(mV)
        a0      = .018		(/ms)	: parameters for alpha and beta
        b0      = .01		(/ms)
        ah      = -43.367	(mV)
        bh      = -43.367	(mV)
        ac      = 9.7054	(mV)
        bc      = -9.7054	(mV)
        q10v    = 3
        celsius			(degC)
}

ASSIGNED {
        v	(mV)
        g	(S/cm2)
        ik	(mA/cm2)
        alpha   (/ms)
        beta    (/ms)
}

STATE {
	c
	o
}

INITIAL {
	SOLVE kin STEADYSTATE sparse
}

BREAKPOINT {
        SOLVE kin METHOD sparse
        g = gbar*o
        ik = g*(v-ek) 
}

KINETIC kin {
        rates(v)
        ~ c <-> o       (alpha, beta)
        CONSERVE c + o = 1
}

PROCEDURE rates(v(mV)) {
        LOCAL qv
        qv = q10v^((celsius-22 (degC))/10 (degC))
        alpha = a0*qv / (1 + exp(-(v-ah)/ac))
        beta = b0*qv / (1 + exp(-(v-bh)/bc))
}

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