D2 dopamine receptor modulation of interneuronal activity (Maurice et al. 2004)

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Accession:98005
"... Using a combination of electrophysiological, molecular, and computational approaches, the studies reported here show that D2 dopamine receptor modulation of Na+ currents underlying autonomous spiking contributes to a slowing of discharge rate, such as that seen in vivo. Four lines of evidence support this conclusion. ... Fourth, simulation of cholinergic interneuron pacemaking revealed that a modest increase in the entry of Na+ channels into the slow-inactivated state was sufficient to account for the slowing of pacemaker discharge. These studies establish a cellular mechanism linking dopamine and the reduction in striatal cholinergic interneuron activity seen in the initial stages of associative learning." See paper for more and details.
Reference:
1 . Maurice N, Mercer J, Chan CS, Hernandez-Lopez S, Held J, Tkatch T, Surmeier DJ (2004) D2 dopamine receptor-mediated modulation of voltage-dependent Na+ channels reduces autonomous activity in striatal cholinergic interneurons. J Neurosci 24:10289-301 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum interneuron cholinergic cell;
Channel(s): I Na,t; I K; I h; I K,Ca; I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s): D2;
Gene(s): D2 DRD2; HCN1; HCN2;
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Action Potentials; Parkinson's;
Implementer(s): Held, Joshua [j-held at northwestern.edu];
Search NeuronDB for information about:  Neostriatum interneuron cholinergic cell; D2; I Na,t; I K; I h; I K,Ca; I Sodium; I Calcium; I Potassium;
:Kir2_ch.MOD
: Kir2, inwardly rectifying channel

NEURON {
	SUFFIX kir2_ch
	USEION k READ ek WRITE ik
	RANGE g, ninf, tn, ik, gbar
	GLOBAL C_tn, vh, vc
}

UNITS {
	(S) = (siemens)
	(mV) = (millivolt)
	(mA) = (milliamp)
}

PARAMETER {
	gbar = 3	(S/cm2)
	ek		(mV)
	vh = -80	(mV)
	vc = 5		(mV)
	C_tn = 1	(ms)
}

ASSIGNED {
	v	(mV)
	ninf
	tn	(ms)
	ik	(mA/cm2)
	g	(S/cm2)
}

STATE {
	n
}

BREAKPOINT {
	SOLVE states METHOD cnexp
	g = gbar*n
	ik = g*(v-ek)
}

DERIVATIVE states{
	values()
	n' = (ninf - n)/tn
}

INITIAL {
	values()
	n = ninf
}

PROCEDURE values() {
	ninf = 1/(1 + exp((v - vh)/vc))
	tn = C_tn
}

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