Conduction in uniform myelinated axons (Moore et al 1978)

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Accession:9851
Examines the relative sensitivity of the velocity of impulse propagation to changes in nodal and internodal parameters.
Reference:
1 . Moore JW, Joyner RW, Brill MH, Waxman SD, Najar-Joa M (1978) Simulations of conduction in uniform myelinated fibers. Relative sensitivity to changes in nodal and internodal parameters. Biophys J 21:147-60 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Axon;
Brain Region(s)/Organism:
Cell Type(s): Myelinated neuron;
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Axonal Action Potentials; Multiple sclerosis;
Implementer(s): Hines, Michael [Michael.Hines at Yale.edu];
Search NeuronDB for information about:  I Na,t; I K;
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moore78
README
cable.hoc
fig2.hoc
fig2.ses
fig3.hoc
fig3.ses
init.hoc
init.ses
mosinit.hoc
                            
Moore, Joyner, Brill, Waxman, and Najar-Joa. (1978) Simulations of
conduction in uniform myelinated fibers: Relative sensitivity to
changes in nodal and internodal parameters.
Biophys. J. 21:147-160.

This model reproduces figures 2 and 3.
The standard temperature for the conductance Q10's is not specified
in the paper. However, fig 3 seems to give quantitatively similar results
when the choice for the "All Q10's" curve is a standard temperature of 0 degC.

The NEURON implementation of this model was prepared by Michael Hines.
Questions about details of this implementation should be addressed to him
at michael.hines@yale.edu.


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