Excitation-contraction coupling/mitochondrial energetics (ECME) model (Cortassa et al. 2006)

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"An intricate network of reactions is involved in matching energy supply with demand in the heart. This complexity arises because energy production both modulates and is modulated by the electrophysiological and contractile activity of the cardiac myocyte. Here, we present an integrated mathematical model of the cardiac cell that links excitation-contraction coupling with mitochondrial energy generation. The dynamics of the model are described by a system of 50 ordinary differential equations. The formulation explicitly incorporates cytoplasmic ATP-consuming processes associated with force generation and ion transport, as well as the creatine kinase reaction. Changes in the electrical and contractile activity of the myocyte are coupled to mitochondrial energetics through the ATP, Ca21, and Na1 concentrations in the myoplasmic and mitochondrial matrix compartments. ..."
1 . Cortassa S, Aon MA, Marbán E, Winslow RL, O'Rourke B (2003) An integrated model of cardiac mitochondrial energy metabolism and calcium dynamics. Biophys J 84:2734-55 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Electrogenic pump;
Brain Region(s)/Organism:
Cell Type(s): Heart cell;
Channel(s): I L high threshold; I Sodium; I Potassium; Na/Ca exchanger; I_SERCA;
Gap Junctions:
Simulation Environment: C or C++ program;
Model Concept(s): Activity Patterns; Temporal Pattern Generation; Signaling pathways; Calcium dynamics;
Search NeuronDB for information about:  I L high threshold; I Sodium; I Potassium; Na/Ca exchanger; I_SERCA;
#pragma once

/*     ----------------------------------------------------


         Copyright 2004, The Johns Hopkins University
            School of Medicine. All rights reserved.
			For research use only; commercial use prohibited.
			Distribution without permission of Raimond L. Winslow
			not permitted. rwinslow@bme.jhu.edu

         Name of Program: Guinea Pig C++: Coupled, Algbraic, BB, MCA
         Version: Documented Version, version 1.0.1
         Date: August 2004


#include <string>
#include <map>
#include <ctype.h>
#include <fstream>
#include <stdlib.h>  
#include <errno.h>  
#include <iomanip>
#include <math.h>
#include <iostream>
#include <time.h>
#include <iterator>
#include <vector>
#include <limits>

//Boost Parsing Library
#include <boost/spirit/core.hpp>
#include <boost/spirit/utility/confix.hpp>
#include <boost/spirit/actor/assign_actor.hpp>
#include <boost/spirit/actor/insert_key_actor.hpp>
#include <boost/spirit/actor/clear_actor.hpp>
#include <boost/spirit/actor/push_back_actor.hpp>
#include <boost/spirit/iterator/file_iterator.hpp> 

#include "Model.h"
#include "states_index.h"

class Model;

using namespace std;
using namespace boost::spirit;

//TODO use boolalpha set on streamsa to autoconvert true/false to boolean and viceversa
class fileIO
	virtual ~fileIO(void);

	void loadFile(const char *ParameterFileName);

	void writeInitialConditionsFile(const char *filename, Model &model);
	void writeInitialConditionsFile(const char *filename, Model &model, const double * states);

	void openOutputFiles(Model* model, const char * statesFilename, const char * currentsFilename, const char * derivativeFilename);
	void writeLnOutputFiles(double * states, double time, Model* model);

	//New data accessors
	const double& operator[](const string &param);
	double getReal(const string &param);
	int getInteger(const string &param);
	const string& getKeyword(const string &param);
	bool getBoolean(const string &param);
	bool parameterExists(const string &param);

	void setupFileOut();
	void finalizeFileOut();
	void closeOutputFiles();

	int MCA_GetNumberOfParameters();
	int MCA_GetNumberOfPercents();
	void MCA_Analyze(Model* model, int param, int percent);
	void MCA_Setup(Model* model);
	void MCA_Update(Model* model, int param, int percent);
	bool MCA_isEnabled();
	typedef map< string, double > realDataType;
	typedef map< string, string > keywordDataType;
	typedef pair< string, double > realDataValueType;
	typedef pair< string, string > keywordDataValueType;
	typedef vector< string > keywordList;
	typedef vector< double > realList;
	typedef map< string, keywordList > keywordListDataType;
	typedef map< string, realList > realListDataType;
	typedef pair< string, keywordList > keywordListDataValueType;
	typedef pair< string, realList > realListDataValueType;
	typedef vector< int > indexList;

	//MCA Stuff
	void MCA_AverageData();

	int MCA_Flux_index;
	bool MCA_Flux_isState;
	int sample_size; //The size of the average/MCA
	realList MCA_percents;
	keywordList MCA_Params;
	double MCA_percent_old;
	double MCA_percent;
	double MCA_param_value;

	//Output mode
	enum OutputMode {Numeric, Average, MCA};
	OutputMode outputMode;

	//File handles:
	ofstream outStates;
	ofstream outCurrents;
	ofstream outDerivatives;
	bool writeDependent;
	bool writestates;
	bool writeDerivatives;

	//New data Storage
	realDataType realData;
	keywordDataType keywordData;

	//List storage types
	keywordListDataType keywordListData;
	realListDataType realListData;

	realList stateMin;
	realList stateMax;
	realList stateAverage;
	realList dependentMin;
	realList dependentMax;
	realList derivativeAverage;
	realList dependentAverage;

	//MCA Only
	realList stateOldAverage;
	realList derivativeOldAverage;
	realList dependentOldAverage;

	//Range storage types, special list limited to 2 or 3 datum
	realListDataType realRangeData;

	//Output variables
	char separator; //tab
	indexList stateIndexes;
	indexList dependentIndexes;
	indexList derivativeIndexes;

	const double * lastState;	

	struct parameterFileGrammer : public grammar<parameterFileGrammer>
        template <typename ScannerT> struct definition
			realDataValueType n;
			keywordDataValueType s;
			keywordListDataValueType sl;
			realListDataValueType nl;

			rule<ScannerT> numPair, strPair, comments, allParams, label, equals;
			rule<ScannerT> rightBrace, leftBrace, seperator, numList, strList, numListPair, strListPair;
			rule<ScannerT> numRange, numRangePair;

			definition(parameterFileGrammer const &self)
				//Shared Grammers
				label = (alpha_p | "_") >> *( alpha_p | digit_p | "_");//Allow underscores in names
				equals = *blank_p >> '=' >> *blank_p;
				comments = comment_p("!") | comment_p("//") | comment_p("/*","*/") | comment_p("%") | space_p;
				//List based grammers
				rightBrace = *comments >> (ch_p(')') | ch_p('}') | ch_p(']'));
				leftBrace  = (ch_p('(') | ch_p('{') | ch_p('[')) >> *comments;
				seperator  =  (*comments >> ch_p(',') >> *comments) | +comments;
				numList = confix_p( 
					leftBrace, real_p[push_back_a(nl.second)] >> *( seperator >> real_p[push_back_a(nl.second)] ), rightBrace );
				strList = confix_p( 
					leftBrace, label[push_back_a(sl.second)] >> *( seperator >> label[push_back_a(sl.second)] ), rightBrace );
				numListPair = confix_p(
					label[assign_a(nl.first)] , equals, numList >> !ch_p(';')
					)[insert_key_a(self.data->realListData,nl)] >> epsilon_p[clear_a(nl.second)];
				strListPair = confix_p(
					label[assign_a(sl.first)] , equals, strList >> !ch_p(';')
					)[insert_key_a(self.data->keywordListData,sl)] >> epsilon_p[clear_a(sl.second)];
				//Range Grammer
				numRange = confix_p( 
					*comments >> real_p[push_back_a(nl.second)] >> *comments >>  ':'  >> *comments >>  real_p[push_back_a(nl.second)] >> *comments >> !(':'  >> *comments >>  real_p[push_back_a(nl.second)] >> *comments),
					rightBrace );
				numRangePair = confix_p(
					label[assign_a(nl.first)] , equals, numRange >> !ch_p(';')
					)[insert_key_a(self.data->realRangeData,nl)] >> epsilon_p[clear_a(nl.second)];
				//Single Parameter Grammers
				numPair = confix_p(
					label[assign_a(n.first)] , equals, real_p[assign_a(n.second)] >> !ch_p(';')
				strPair = confix_p(
					label[assign_a(s.first)] , equals, label[assign_a(s.second)] >> !ch_p(';') 
				//Complete Grammer
				allParams = *(numPair | strPair | comments | strListPair | numListPair | numRangePair );
            rule<ScannerT> const& start() const { return allParams; }
		parameterFileGrammer(fileIO *dataStore) {
			data = dataStore;
		fileIO * data;
	friend parameterFileGrammer;

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