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CA1 pyramidal neuron: h channel-dependent deficit of theta oscill. resonance (Marcelin et al. 2008)
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Accession:
116983
This model was used to confirm and support experimental data suggesting that the neuronal/circuitry changes associated with temporal lobe epilepsy, including Ih-dependent inductive mechanisms, can disrupt hippocampal theta function.
Reference:
1 .
Marcelin B, Chauvière L, Becker A, Migliore M, Esclapez M, Bernard C (2009) h channel-dependent deficit of theta oscillation resonance and phase shift in temporal lobe epilepsy.
Neurobiol Dis
33
:436-47
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Dendrite;
Brain Region(s)/Organism:
Hippocampus;
Cell Type(s):
Hippocampus CA1 pyramidal GLU cell;
Channel(s):
I h;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Oscillations;
Detailed Neuronal Models;
Epilepsy;
Implementer(s):
Migliore, Michele [Michele.Migliore at Yale.edu];
Search NeuronDB
for information about:
Hippocampus CA1 pyramidal GLU cell
;
I h
;
/
theta
readme.html
h.mod
fixnseg.hoc
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geoc62564.hoc
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ondelette-No-Gain-1-4Hz.txt
screenshot.jpg
theta.hoc
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