Action Potential initiation and backpropagation in Neocortical L5 Pyramidal Neuron (Hu et al. 2009)

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"...Previous computational studies have yielded conflicting conclusions about the role of Na+ channel density and biophysical properties in action potential initiation as a result of inconsistent estimates of channel density. Our modeling studies integrated the immunostaining and electrophysiological results and showed that the lowest threshold for action potential initiation at the distal AIS was largely determined by the density of low-threshold Nav1.6 channels ... Distinct from the function of Nav1.6 channel, the Nav1.2 channel may control action potential backpropagation because of its high density at the proximal AIS and high threshold. ... In conclusion, distal AIS accumulation of Nav1.6 channels determines the low threshold for action potential initiation; whereas proximal AIS accumulation of Nav1.2 channels sets the threshold for the generation of somatodendritic potentials and ensures action potential backpropagation to the soma and dendrites. Thus, Nav1.6 and Nav1.2 channels serve distinct functions in action potential initiation and backpropagation."
1 . Hu W, Tian C, Li T, Yang M, Hou H, Shu Y (2009) Distinct contributions of Na(v)1.6 and Na(v)1.2 in action potential initiation and backpropagation. Nat Neurosci 12:996-1002 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Axon; Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s): Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell; Neocortex U1 L5B pyramidal pyramidal tract GLU cell;
Channel(s): I K; I M; I K,Ca; I Sodium; I Calcium;
Gap Junctions:
Gene(s): Nav1.2 SCN2A; Nav1.6 SCN8A;
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Ion Channel Kinetics; Axonal Action Potentials;
Implementer(s): Hu, Wenqin [huwenqin at]; Hou, Han [hh at];
Search NeuronDB for information about:  Neocortex U1 L5B pyramidal pyramidal tract GLU cell; Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell; I K; I M; I K,Ca; I Sodium; I Calcium;
 /* --------------------------------------------------------------
   Distinct contributions of Nav1.6 and Nav1.2 in action potential initiation and backpropagation
   Wenqin Hu, Cuiping Tian, Tun Li, Mingpo Yang, Han Hou, Yousheng Shu
   Model based on:   
   Z. F. Mainen and T. J. Sejnowski (1996)  dendritic structure 
   Shu et al. (2006) artifical axonal structure

   Wenqin Hu
   Han Hou
------------------------------------------------------------- */

objref p
p=new PWManager() 



proc Pyramidal(){
  forall delete_section()
  xopen ("experiment/Pyramidal_Main.hoc")  

proc UniformAxon(){
  forall delete_section()
  xopen ("experiment/UniformAxon_Main.hoc")  

proc SingleComp(){
  forall delete_section()
  xopen ("experiment/SingleComp_Main.hoc")  

/* ----------------------------------------------
  Initial Menu

xpanel("Nav1.6 and Nav1.2",0)
  xbutton( " 1. Action Potential Initiation in Neocortical L5 Pyramidal Cell (Figure 5d,e)", " Pyramidal()")
  xbutton( " 2. Action Potential Initiation in Uniform Axon (Figure 5b,c)", " UniformAxon()")
  xbutton( " 3. Channel Tests in Single Compartment Model", " SingleComp()")

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