ModelDB: Failure of Deep Brain Stimulation in a basal ganglia neuronal network model (Dovzhenok et al. 2013)

Failure of Deep Brain Stimulation in a basal ganglia neuronal network model (Dovzhenok et al. 2013)

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Accession:148637

"… Recently, a lot of interest has been devoted to desynchronizing delayed feedback deep brain stimulation (DBS). ... This study explores the action of delayed feedback stimulation on partially synchronized oscillatory dynamics, similar to what one observes experimentally in parkinsonian patients. …" Implemented by Andrey Dovzhenok, to whom questions should be addressed.
Reference:
1 . Dovzhenok A, Park C, Worth RM, Rubchinsky LL (2013) Failure of delayed feedback deep brain stimulation for intermittent pathological synchronization in Parkinson's disease. PLoS One 8:e58264 [PubMed]

Model Information (Click on a link to find other models with that property)

Model Type:	Realistic Network;
Brain Region(s)/Organism:	Basal ganglia;
Cell Type(s):	Subthalamus nucleus projection neuron; Globus pallidus neuron;
Channel(s):	I Na,t; I T low threshold; I K; I_AHP; I Ca,p;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	XPP; MATLAB;
Model Concept(s):	Synchronization; Parkinson's; Deep brain stimulation;
Implementer(s):	Dovzhenok, Andrey [andrey.dovzhenok at uc.edu];