We developed a novel multiscale model to bridge neuropeptide receptor-activated signaling pathway with membrane electrophysiology.
The model studies the effects of Angiotensin II (AngII) on neuronal excitability changes mediated by signaling dynamics and downstream
phosphorylation of ion channels. The multiscale model was implemented as a set of ordinary differential equations solved using the ode15s
solver in Matlab (Mathworks, USA). The signaling reactions were modeled with either mass-action or Michaelis--Menten kinetics and ion
channel electrophysiology was modeled according to the Hodgkin-Huxley formalism. These models were initially validated against their
respective data domains independently and were integrated to develop a multiscale model of signaling and electrophysiology.
Makadia HK, Anderson WD, Fey D, Sauter T, Schwaber JS, Vadigepalli R (2015) Multiscale model of dynamic neuromodulation integrating neuropeptide-induced signaling pathway activity with membrane electrophysiology. Biophys J 108:211-23 [PubMed]