This is the readme for models associated with the paper:
Alex Pavlides, S. John Hogan and Rafal Bogacz. (2015) Computational
models describing possible mechanisms for generation of excessive beta
oscillations in Parkinson's disease. PLOS Computational Biology
This set of Matlab files produce a figure showing Results of simulations of the resonance model (panels A and B) and feedback model (panels C and D). A, C) Each of the six panels shows the activity of the STN, GPe and cortical populations as a function of time. The labels to the left indicate if a row shows simulations of an intact model, or a model with particular connections blocked. In simulations in panel A the following parameters were used: wSG =4.87, wGS=1.33, wCS=9.98, wSC=8.93, wGG=0.53, wCC=6.17, C=172.18, Str=8.46, TCC=4.65, tau_E=11.59, tau_I=13.02, B_E=17.85, B_I=9.87, M_E=75.77 and M_I=205.72. In simulations in panel C the following values were used: wSG=2.56, wGS=3.22, wCS=6.60, wSC= 0.00, wGG=0.90, wCC=3.08, C=277.94, Str=40.51, TCC=7.74, tau_E=11.69, tau_I=10.45, B_E=3.62, B_I=7.18, M_E=71.77 and M_I=276.39. B, D) The comparison between experimental and simulated statistics of the oscillations.
Ensure files and data are availabe in Matlab. To run type 'main' at the command line. The figure should be generated.
Contact: If there are any questions please contact Dr Rafal Bogacz by email: email@example.com