Synchronized oscillations of clock gene expression in the choroid plexus (Myung et al 2018)

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Our model simulates synchronized rhythms in the clock gene expression found in the choroid plexus. These synchronized oscillations, primarily mediated by gap junctions, showed interesting relationships between their amplitude, oscillation frequency, and coupling strength (gap junction density) in our experimental data. The model is based on coupled Poincaré oscillators and replicates this phenomenon via a non-zero "twist" in each cell.
1 . Myung J, Schmal C, Hong S, Tsukizawa Y, Rose P, Zhang Y, Holtzman MJ, De Schutter E, Herzel H, Bordyugov G, Takumi T (2018) The choroid plexus is an important circadian clock component. Nat Commun 9:1062 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Gap Junctions: Gap junctions;
Simulation Environment: MATLAB; Python; Mathematica;
Model Concept(s): Oscillations; Synchronization; Circadian Rhythms; Temporal Pattern Generation; Activity Patterns;
Implementer(s): Hong, Sungho [shhong at]; Schmal, Christoph ; Myung, Jihwan ;
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