Comprehensive models of human cortical pyramidal neurons (Eyal et al 2018)


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Accession:238347
"We present detailed models of pyramidal cells from human neocortex, including models on their excitatory synapses, dendritic spines, dendritic NMDA- and somatic/axonal Na+ spikes that provided new insights into signal processing and computational capabilities of these principal cells. Six human layer 2 and layer 3 pyramidal cells (HL2/L3 PCs) were modeled, integrating detailed anatomical and physiological data from both fresh and postmortem tissues from human temporal cortex. The models predicted particularly large AMPA- and NMDA- conductances per synaptic contact (0.88 nS and 1.31nS, respectively) and a steep dependence of the NMDA-conductance on voltage..."
Reference:
1 . Eyal G, Verhoog MB, Testa-Silva G, Deitcher Y, Benavides-Piccione R, DeFelipe J, de Kock CP, Mansvelder HD, Segev I (2018) Human Cortical Pyramidal Neurons: From Spines to Spikes via Models Front Cell Neurosci 12:181 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Dendrite; Axon; Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Human; Neocortex;
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON (web link to model); Python (web link to model);
Model Concept(s):
Implementer(s): Eyal, Guy [guy.eyal at mail.huji.ac.il];
Search NeuronDB for information about:  AMPA; NMDA;
(located via links below)
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