"Despite advances in experimental techniques and accumulation of large datasets concerning
the composition and properties of the cortex, quantitative modeling of cortical circuits
under in-vivo-like conditions remains challenging. Here we report and publicly release a biophysically
detailed circuit model of layer 4 in the mouse primary visual cortex, receiving thalamo-
cortical visual inputs. The 45,000-neuron model was subjected to a battery of visual
stimuli, and results were compared to published work and new in vivo experiments. ..."
Arkhipov A, Gouwens NW, Billeh YN, Gratiy S, Iyer R, Wei Z, Xu Z, Abbasi-Asl R, Berg J, Buice M, Cain N, da Costa N, de Vries S, Denman D, Durand S, Feng D, Jarsky T, Lecoq J, Lee B, Li L, Mihalas S, Ocker GK, Olsen SR, Reid RC, Soler-Llavina G, Sorensen SA, Wang Q, Waters J, Scanziani M, Koch C (2018) Visual physiology of the layer 4 cortical circuit in silico. PLoS Comput Biol 14:e1006535 [PubMed]