Influence of dendritic structure on neocortical neuron firing patterns (Mainen and Sejnowski 1996)

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Accession:2488
This package contains compartmental models of four reconstructed neocortical neurons (layer 3 Aspiny, layer 4 Stellate, layer 3 and layer 5 Pyramidal neurons) with active dendritic currents using NEURON. Running this simulation demonstrates that an entire spectrum of firing patterns can be reproduced in this set of model neurons which share a common distribution of ion channels and differ only in their dendritic geometry. The reference paper is: Z. F. Mainen and T. J. Sejnowski (1996) Influence of dendritic structure on firing pattern in model neocortical neurons. Nature 382: 363-366. See also http://www.cnl.salk.edu/~zach/methods.html and http://www.cnl.salk.edu/~zach/ More info in readme.txt file below made visible by clicking on the patdemo folder and then on the readme.txt file.
Reference:
1 . Mainen ZF, Sejnowski TJ (1996) Influence of dendritic structure on firing pattern in model neocortical neurons. Nature 382:363-6 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex L5/6 pyramidal GLU cell; Neocortex L2/3 pyramidal GLU cell; Myelinated neuron; Neocortex spiny stellate cell;
Channel(s): I Na,t; I K; I M; I K,Ca; I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Active Dendrites; Influence of Dendritic Geometry; Detailed Neuronal Models;
Implementer(s): Mainen, Zach [Mainen at cshl.edu];
Search NeuronDB for information about:  Neocortex L5/6 pyramidal GLU cell; Neocortex L2/3 pyramidal GLU cell; I Na,t; I K; I M; I K,Ca; I Sodium; I Calcium; I Potassium;
load_file("nrngui.hoc")

pwmcnt = PWManager[0].count // used to hide this panel after fig selected

xpanel("Select a figure")
  xbutton("Figure 1 demo","fig_1()")
  xbutton("Figure 2 demo","fig_2()")
  xlabel("after selecting a figure choose cell or parameters")
  xlabel("then press Init & Run")
xpanel()

proc fig_1() {
  PWManager[0].hide(pwmcnt-1)
  xopen("demofig1.hoc")
}

proc fig_2() {
  PWManager[0].hide(pwmcnt-1)
  xopen("initfig2.hoc")
}

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