ModelDB: Double cable myelinated axon (Layer 5 pyramidal neuron; Cohen et al 2020)

Double cable myelinated axon (Layer 5 pyramidal neuron; Cohen et al 2020)

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Accession:260967

The periaxonal space in myelinated axons is conductive (~50 ohm cm). Together with a rapidly charging myelin sheath and relatively sealed paranodes, periaxonal conduction shapes the saltating voltage profiles of transaxonal (Vm), transmyelin (Vmy) and transfibre (Vmym) potentials. This model exemplifies double cable saltatory conduction across both time and space, and is the same cell (#6) as seen in Movie S4 of Cohen et al. 2020. This model version allows one to visualize and manipulate the controlling parameters of a propagating action potential. Further notes: The corresponding potentials in NEURON to those named above are v, vext (or vext[0]) and v+vext, respectively. The loaded biophysical parameters were those optimized for this cell (Cohen et al. 2020).
Reference:
1 . Cohen CCH, Popovic MA, Klooster J, Weil M, Möbius W, Nave K, Kole MHP (2020) Saltatory Conduction along Myelinated Axons Involves a Periaxonal Nanocircuit Cell

Model Information (Click on a link to find other models with that property)

Model Type:	Axon; Channel/Receptor; Dendrite; Extracellular; Glia; Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):	Neocortex L5/6 pyramidal GLU cell; Myelinated neuron;
Channel(s):	Ca pump; I Calcium; I h; I K,Ca; I K,leak; I L high threshold; I T low threshold; I M; I Na,p; I Na,t; I Sodium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	NEURON;
Model Concept(s):	Action Potentials; Active Dendrites; Axonal Action Potentials; Conductance distributions; Conductances estimation; Detailed Neuronal Models; Electrotonus; Extracellular Fields; Membrane Properties; Multiple sclerosis; Parameter sensitivity; Double cable;
Implementer(s):	Cohen, Charles CH [c.cohen at gmx.com]; Kole, Maarten [m.kole at nin.knaw.nl];