The microcircuits of striatum in silico (Hjorth et al 2020)


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Accession:265540
"Our aim is to reconstruct a full-scale mouse striatal cellular level model to provide a framework to integrate and interpret striatal data. We represent the main striatal neuronal subtypes, the two types of projection neurons (dSPNs and iSPNs) giving rise to the direct and indirect pathways, the fast-spiking interneurons, the low threshold spiking interneurons, and the cholinergic interneurons as detailed compartmental models, with properties close to their biological counterparts. Both intrastriatal and afferent synaptic inputs (cortex, thalamus, dopamine system) are optimized against existing data, including short-term plasticity. This model platform will be used to generate new hypotheses on striatal function or network dynamic phenomena."
Reference:
1 . Hjorth JJJ, Kozlov A, Carannante I, Frost Nylén J, Lindroos R, Johansson Y, Tokarska A, Dorst MC, Suryanarayana SM, Silberberg G, Hellgren Kotaleski J, Grillner S (2020) The microcircuits of striatum in silico. Proc Natl Acad Sci U S A 117:9554-9565 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Striatum; Basal ganglia;
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; Neostriatum interneuron ACh cell; Neostriatum interneuron gaba/parvalbumin GABA cell; Neostriatum interneuron SOM/NOS GABA cell; Neostriatum spiny neuron; Neostriatum fast spiking interneuron;
Channel(s): I Na,t; I K; I A; I A, slow; I T low threshold; I K,Ca; I N; I Q; I R; Kir;
Gap Junctions:
Receptor(s):
Gene(s): Cav2.1 CACNA1A; Cav2.2 CACNA1B; Cav3.1 CACNA1G; Cav3.2 CACNA1H;
Transmitter(s):
Simulation Environment: NEURON (web link to model); Snudda (web link to model);
Model Concept(s): Methods;
Implementer(s): Hjorth, Johannes [hjorth at csc.kth.se];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; Neostriatum interneuron ACh cell; Neostriatum medium spiny indirect pathway GABA cell; Neostriatum interneuron gaba/parvalbumin GABA cell; Neostriatum interneuron SOM/NOS GABA cell; I Na,t; I N; I T low threshold; I A; I K; I K,Ca; I A, slow; I R; I Q; Kir;
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