The Golgi cells are the main inhibitory interneurons of the cerebellar granular layer. To study the mechanisms through which these neurons integrate complex input patterns, a new set of models were developed using the latest experimental information and a genetic algorithm approach to fit the maximum ionic channel conductances. The models faithfully reproduced a rich pattern of electrophysiological and pharmacological properties and predicted the operating mechanisms of these neurons.
Masoli S, Ottaviani A, Casali S, D'Angelo E (2020) Cerebellar Golgi cell models predict dendritic processing and mechanisms of synaptic plasticity. PLoS Comput Biol 16:e1007937 [PubMed]