Coincident glutamatergic depolarization effects on Cl- dynamics (Lombardi et al, 2021)

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Accession:266823
"... we used compartmental biophysical models of Cl- dynamics simulating either a simple ball-and-stick topology or a reconstructed CA3 neuron. These computational experiments demonstrated that glutamatergic co-stimulation enhances GABA receptor-mediated Cl- influx at low and attenuates or reverses the Cl- efflux at high initial [Cl-]i. The size of glutamatergic influence on GABAergic Cl--fluxes depends on the conductance, decay kinetics, and localization of glutamatergic inputs. Surprisingly, the glutamatergic shift in GABAergic Cl--fluxes is invariant to latencies between GABAergic and glutamatergic inputs over a substantial interval..."
Reference:
1 . Lombardi A, Jedlicka P, Luhmann HJ, Kilb W (2021) Coincident glutamatergic depolarizations enhance GABAA receptor-dependent Cl- influx in mature and suppress Cl- efflux in immature neurons PLOS Comp Bio
Model Information (Click on a link to find other models with that property)
Model Type: Synapse; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA3 pyramidal GLU cell;
Channel(s):
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Short-term Synaptic Plasticity; Synaptic Plasticity; Chloride regulation;
Implementer(s): Jedlicka, Peter [jedlicka at em.uni-frankfurt.de]; Kilb, Werner [wkilb at uni-mainz.de];
Search NeuronDB for information about:  Hippocampus CA3 pyramidal GLU cell; GabaA; AMPA; NMDA; Gaba; Glutamate;
This folders contain the .hoc, .ses and .mod files used for the manuscript:

"Coincident glutamatergic depolarizations enhance GABAA receptor-dependent 
Cl- influx in mature and suppress Cl- efflux in immature neurons"

by Aniello Lombardi, Peter Jedlicka, Heiko J. Luhmann, and Werner Kilb

To run the programs you first have to compile the .mod files using mknrndll for EACH folder.

The simulations are ordered in seperate folders according to the figures/panes in the manuscript. They should run from
each folder after compiling the .mod-files.

The essential parts of the models (mod-files for the GABA-currents and Chloride-Bicarbonate-handling
as well as the hoc-file with the reconstructed CA3 hippocampal neuron) are in addition isoltaed to
the folder "Essential Elements". 

The simulations can by automatically started using the Start_xxx.hoc files. 

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