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Ventromedial Thalamocortical Neuron (Bichler et al 2021)
 
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Model Information
Model File
Citations
Accession:
266989
"Biophysical computer modeling of a thalamic neuron demonstrated that an increase in rebound spiking can also be accounted for by a decrease in the M-type potassium current. Modeling also showed that an increase in sag with hyperpolarizing steps found after 6-OHDA treatment could in part but not fully be accounted for by the decrease in M-type current. These findings support the hypothesis that homeostatic changes in BGMT neural properties following 6-OHDA treatment likely influence the signal processing taking place in the BG thalamocortical network in Parkinson's disease."
Reference:
1 .
Bichler EK, Cavarretta F, Jaeger D (2021) Changes in Excitability Properties of Ventromedial Motor Thalamic Neurons in 6-OHDA Lesioned Mice.
eNeuro
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Thalamus;
Cell Type(s):
Channel(s):
I A;
I h;
I L high threshold;
I T low threshold;
I K,Ca;
I Sodium;
I Potassium;
I Na,p;
I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Python;
Model Concept(s):
Pathophysiology;
Implementer(s):
Search NeuronDB
for information about:
I Na,p
;
I L high threshold
;
I T low threshold
;
I A
;
I K
;
I h
;
I K,Ca
;
I Sodium
;
I Potassium
;
/
VMThalamocorticalNeuronModel
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