Hyperexcitability from Nav1.2 channel loss in neocortical pyramidal cells (Spratt et al accepted)

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Based on the Layer 5 thick-tufted pyramidal cell from the Blue Brain Project, we modify the distribution of the sodium channel Nav1.2 to recapitulate an increase in excitability observed in ex vivo slice experiments.
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Prefrontal cortex (PFC);
Cell Type(s): Neocortex layer 5 pyramidal cell;
Channel(s): I h; I M; I Potassium; I Sodium; I L high threshold; I T low threshold;
Gap Junctions:
Gene(s): Nav1.2 SCN2A;
Simulation Environment: NEURON; Python;
Model Concept(s):
Implementer(s): Ben-Shalom, Roy [rbenshalom at ucdavis.edu]; Kyoung, Henry [hkyoung at berkeley.edu];
Search NeuronDB for information about:  I L high threshold; I T low threshold; I M; I h; I Sodium; I Potassium;
Na12 Analysis
Ri Increase
# Scn2a Compartmental Model

Models and Jupyter notebooks for:

** Paper reference **

The simulations were tested with:

- Python v3.8.5

- NEURON v8.0

Model in ./Na12 Analysis/NaV12_analysis.ipynb corresponds to Figure 3, S3A-B, S4.

Model in ./Ri Increase/25% Ri Increase Figures.ipynb corresponds to Figure S3C.

Compile in mechanisms folder by running shell command `nrnivmodl` (Mac)/`mknrndll` (Windows) and copy x86_64 folder (Mac)/nrnmech.dll (Windows) to model folder.

For additional information, please contact bens.roy@gmail.com or henry.kyoung@ucsf.edu