Dynamics of ramping bursts in a respiratory pre-Botzinger Complex model (Abdulla et al, 2021)

 Download zip file 
Help downloading and running models
This single-neuron model is, to the authors' knowledge, the first to capture the pre-inspiratory ramping aspects of preBotzinger Complex inspiratory neurons' activity patterns, in which relatively slow tonic spiking gradually progresses to faster spiking and a full-blown burst, with a corresponding gradual development of an underlying plateau potential. The key to this pattern is the incorporation of the dynamics of the extracellular potassium ion concentration, which is here integrated into an existing model for pre-BotC neuron bursting along with some parameter adjustments. Using fast-slow decomposition, this activity can be shown to be a form of parabolic bursting, but with burst termination at a homoclinic bifurcation rather than at a SNIC bifurcation.
1 . Abdulla M, Phillips R, Rubin J (2021) Dynamics of ramping bursts in a respiratory neuron model J. Comp. Neurosci. [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Brainstem;
Cell Type(s): PreBotzinger complex neuron;
Channel(s): I Na, slow inactivation;
Gap Junctions:
Simulation Environment: XPP;
Model Concept(s): Bursting; Dynamic extracellular concentrations; Ramping;
Implementer(s): Abdulla, Muhammad [muhammadabdulla at ufl.edu]; Phillips, Ryan [ryanp at pitt.edu]; Rubin, Jonathan E [jonrubin at pitt.edu];
Search NeuronDB for information about:  I Na, slow inactivation;
File not selected

<- Select file from this column.
Loading data, please wait...