Locus Coeruleus blocking model (Chowdhury et al. accepted)

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"... Here, we show that Locus Coeruleus (LC) cells projecting to dCA1 have a key permissive role in contextual memory linking, without affecting contextual memory formation, and that this effect is mediated by dopamine. Additionally, we found that LC to dCA1 projecting neurons modulate the excitability of dCA1 neurons, and the extent of overlap between dCA1 memory ensembles, as well as the stability of coactivity patterns within these ensembles..."
1 . Chowdhury A, Luchetti A, Fernandes G, Filho DA, Kastellakis G, Tzilivaki A, Ramirez EM, Tran MY, Poirazi P, Silva AJ (accepted) A Locus Coeruleus- dorsal CA1 dopaminergic circuit modulates memory linking Neuron
2 . Kastellakis G, Silva AJ, Poirazi P (2016) Linking Memories across Time via Neuronal and Dendritic Overlaps in Model Neurons with Active Dendrites. Cell Rep 17:1491-1504 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Spiking neural network; Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Abstract integrate-and-fire neuron;
Gap Junctions:
Receptor(s): AMPA; NMDA; Gaba;
Simulation Environment: C or C++ program; Python;
Model Concept(s): Long-term Synaptic Plasticity; Synaptic Tagging and Capture; Hebbian plasticity; Calcium dynamics; Excitability;
Implementer(s): Kastellakis, George [gkastel at];
Search NeuronDB for information about:  AMPA; NMDA; Gaba;
This folder contains the computational model for model for:
Chowdhury et al. 2022 'A Locus Coeruleus- dorsal CA1 dopaminergic circuit modulates memory linking'

The model was built with the following requirements:

g++ : version 9.3.0
python 3 (v3.8.5) with numpy + matplotlib
make: v 4.2.1
bash: v 5.0.17

License: GPLv2

To generate data data and figures use the following command:

> bash

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