CA1 pyramidal neuron: Synaptic Scaling (Magee, Cook 2000)

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Accession:7509
Jeffrey Magee and Erik Cook found evidence in experiments and modeling that support the hypothesis that an increase in synaptic conductance for synapses at larger distances from the soma is responsible for reducing the location dependence (relative to the soma) of synapses.
Reference:
1 . Magee JC, Cook EP (2000) Somatic EPSP amplitude is independent of synapse location in hippocampal pyramidal neurons. Nat Neurosci 3:895-903 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s):
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Influence of Dendritic Geometry;
Implementer(s): Magee, Jeffrey [jmagee at lsumc.edu];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; AMPA;
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magee2000
readme.txt
ca1.nrn
main.hoc
main_example_epsps.hoc
mosinit.hoc
shape_plot.ses
                            
load_file("nrngui.hoc")

objref fig4_box, fig4_subbox_ab, fig4_subbox_cd, shape_plot_win
fig4_box = new VBox()
fig4_box.intercept(1)

	xpanel("ab")
	fig4_subbox_ab = new HBox()
	xpanel()

	fig4_subbox_ab.intercept(1)


		xpanel("b")
		load_file("main.hoc")
		xpanel()

	fig4_subbox_ab.intercept(0)

	fig4_subbox_cd = new HBox()
	fig4_subbox_cd.intercept(1)

		xpanel("c")
		load_file("main_example_epsps.hoc")
		xpanel()

	fig4_subbox_cd.intercept(0)
	fig4_subbox_cd.map()

// now that shape is loaded add the morphology graph
	fig4_subbox_ab.intercept(1)

		load_file("shape_plot.ses")
		
	fig4_subbox_ab.intercept(0)
	fig4_subbox_ab.map()

fig4_box.intercept(0)
fig4_box.map()

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