Model of cerebellar parallel fiber-Purkinje cell LTD and LTP (Gallimore et al 2018)

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Accession:235376
Model of cerebellar parallel fiber-Purkinje cell LTD and LTP implemented in Matlab Simbiology
Reference:
1 . Gallimore AR, Kim T, Tanaka-Yamamoto K, De Schutter E (2018) Switching On Depression and Potentiation in the Cerebellum. Cell Rep 22:722-733 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Molecular Network; Synapse;
Brain Region(s)/Organism: Cerebellum;
Cell Type(s): Cerebellum Purkinje GABA cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: MATLAB;
Model Concept(s): Long-term Synaptic Plasticity; Synaptic Plasticity; Learning; Depression;
Implementer(s): Gallimore, Andrew R [andrew.gallimore at oist.jp];
Search NeuronDB for information about:  Cerebellum Purkinje GABA cell;
%%%%%Parallel Fiber Glutamate and Calcium Pulse%%%%%%%
function pf_pulse_ltp(pulse_time)
	global pfpc_model;
	label = num2str(pulse_time*200);
	event_name = ['event' label];
	glu_on = [event_name 'glu_on'];
	glu_off = [event_name 'glu_off'];
	ca_on = [event_name 'ca_on'];
	ca_off = [event_name 'ca_off'];
	off_time = pulse_time+0.001;
	%Create parameters
	on_param = [event_name 'on'];
	time_on_cond = ['time >= ' on_param];
	on_param = addparameter(pfpc_model,on_param, 'Value', pulse_time, 'ValueUnits', 'second')
	off_param = [event_name 'off'];
	time_off_cond = ['time >= ' off_param];
	off_param = addparameter(pfpc_model,off_param, 'Value', off_time, 'ValueUnits', 'second')
	%create triggers for glu and ca
	glu_on = addevent(pfpc_model, time_on_cond, 'kinflux_glu = glu_pulse')
	glu_off = addevent(pfpc_model, time_off_cond, 'kinflux_glu = 0')
	ca_on = addevent(pfpc_model, time_on_cond, 'kinflux_pf = ca_pulse')
	ca_off = addevent(pfpc_model, time_off_cond, 'kinflux_pf = 0')
end

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