Membrane Channels: Inventory of genes and gene products
This page gives a complete overview of the main types of membrane channels that have been identified in excitable membranes. The list of membrane currents for NeuronDB is a subset of this inventory. The inventory is based on Hille (2001). The inventory is in terms of genes and gene products.
Na channels Ca channels K channels and related channels
Channel name | Human gene name | Human chromosome | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Nav1.1 | SCN1A | 2q24 | ||||||||
Nav1.2 | SCN2A | 2q23-24 | ||||||||
Nav1.3 | SCN3A | 2q24 | ||||||||
Nav1.4 | SCN4A | 17q23-25 | ||||||||
Nav1.5 | SCN5A | 3p21 | ||||||||
Nav1.6 | SCN8A | 12q13 | ||||||||
Nav1.7 | SCN9A | 2q24 | ||||||||
Nav1.8 | SCN10A | 3p22-24 | ||||||||
Nav1.9 | SCN11A | 3p21-24 |
Abbreviations:
Channel name | Human gene name | Human chromosome | ||
---|---|---|---|---|
HVA | L | Cav1.1 | CACNA1S | 1q31-32 |
Cav1.2 | CACNA1C | 12p13.33 | ||
Cav1.3 | CACNA1D | 3p14.3 | ||
Cav1.4 | CACNA1F | Xp11.23 | ||
P/Q | Cav2.1 | CACNA1A | 19p13 | |
N | Cav2.2 | CACNA1B | 9q34 | |
R | Cav2.3 | CACNA1E | 1q25-31 | |
LVA T | Cav3.1 | CACNA1G | 17q22 | |
Cav3.2 | CACNA1H | 16p13.2 | ||
Cav3.3 | CACNA1I | 22q12 |
Abbreviations:
Subfamily | Human gene prefix | Phenotype | Biophysical feature | |
---|---|---|---|---|
6TM | NCN1 | HCN | Hyperpolarization-activated | Nonselective cation channels |
CNG1 | CNG | Cyclic nucleotide-gated | ||
eag | KCNH | Voltage-gated ether a-go-go | ||
akt1 | Plant inward rectifiers | |||
pak1 | Paramecium | |||
mslo | KCNM | Large conductance (BK) voltage/calcium-gated | ||
SK1 | KCNN | Small and intermdiate conductance calcium-activated | ||
Kv1.1 | KCNA | Voltage-gated shakers | Delayed-rectifiers and A-type | |
Kv2.1 | KCNB | Voltage-gated shabs | ||
Kv3.1 | KCNC | Voltage-gated shaws | ||
Kv4.1 | KCND | Voltage-gated shals | ||
Kv5.1 | Voltage-gated outlier | |||
Kv6.1 | Modifiers/silencers | |||
Kv7.1=KCNQ1 | KCNQX=Kv7.X | Voltage-gated KCNQs | Slow delayed-rectifiers (M-Current is a heteromeric assembly of KCNQ2 and KCNQ3 subunits) | |
Kv8.1 | Modifiers/silencers | Delayed-rectifiers | ||
Kv9.1 | KCNS | Modifiers/silencers | ||
2TM | Kir4.1 | KCNH | Inward rectifiers | Classical inward rectifiers |
Kir7.1 | ||||
Kir1.1 | ||||
Kir2.1 | ||||
Kir5.1 | ||||
Kir6.1 | ATP-sensitive | |||
Kir3.1 | G-protein-coupled | |||
4TM | TWIK | KCNK | 2-P-domain K leaks |
Abbreviations:
Reference
Hille, B. (2001) Ion Channels of Excitable Membrane (3rd Edition). Sunderland, Mass. Sinauer Associates, Inc. K channels from the cardiovascular cell physiology group at Philipps-University Marburg