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The following list is a subset of the membrane channels inventory in NeuronDB.

Neuronal Ionic Currents

Comparitive Search: clicking on a current shows all cells and all compartments within those cells which contain that current.

I Sodium
I Na,t"Transient"; rapidly inactivatingAction potentials
I Na,pPersistent (plateau); non-inactivating; TTX-resistantEnhances depolarizations; contributes to steady-state firing
I Potassium
I A, slowSlowly inactivating "delay" current I K(D)Similar to A-type current but inactivates slowly (seconds). Participates in spike repolarization.
I A"Transient"; inactivatingDelayed onset of firing; interspike interval; action potential repolarization
I K,leakContributes to neuronal resting "leak"conductanceHelps determine resting membrane potential
I KActivated by strong depolarization; delayed rectifierRepolarization of action potential
I MActivated by depolarization above -65 mV; slow, weak and non-inactivating; blocked by ligands like acetylcholine acting through muscarinic (M) receptorsContributes to slow spike frequency adaptation
I Calcium
I L high threshold"Long-lasting"; slowly inactivating; threshold around -20 mVUnderlies Ca2+ spikes that are prominent in dendrites; involved in synaptic transmission
I N"Neither"; rapidly inactivating; threshold around -20 mVUnderlies Ca2+ spikes that are prominent in dendrites; involved in synaptic transmission
I T low threshold"Transient"; rapidly inactivating, threshold negative to -65mVUnderlies rhythmic burst firing; some dendritic action potentials
I p,qIncludes both p-type and q-type currents
I Chloride
I Cl,CaCalcium activated chloride currentCan enhance or decrease response depending on the Cl- equilibrium potential
I Mixed
I K,CaIncludes BK, IK, SK, and I AHP currents; K current activated by increases in [Ca2+]i; voltage dependence variesAction potential repolarization and interspike interval
I CNGCyclic-Nucleotide Gated nonspecific cation channelDark current in photoreceptors, activated by cGMP; light response in ON retinal bipolar cells; receptor current in olfactory sensory neurons, activated by cAMP, modulated by cGMP; found widely in CNS neurons
I CANCalcium Activated Nonspecific cation channel
I hInward rectifier; "Queer"; activated by hyperpolarization/mixed cation currentPrevents strong hyperpolarization; increases membrane resistance during membrane depolarization

This database was supported by the Human Brain Project (NIDCD, NIMH, NIA, NICD, NINDS) and MURI (Multidisciplinary University Research Initiative). It is now supported by RO1 DC 009977 from the National Institute for Deafness and other Communication Disorders. NeuronDB Credits
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