1. Chen WR, Xiong W and Shepherd GM. (2000) Analysis of relations between NMDA receptors and GABA release at olfactory bulb reciprocal synapses. Neuron 25:625-33.

NeuronCompartmentPropertyConnectivityNotes
Olfactory bulb main interneuron granule MC GABA cellDistal equivalent dendriteNMDAfrom mitral cellNMDA receptor is required for DDI (dendrodendritic inhibition) since IPSC was completely blocked by AP-5. Ineffectiveness of AMPA receptor-mediated EPSPs to activate the granule cells may be due to their intrinsic membrane properties. (Schoppa NE et al, 19982 ). NMDA receptors play a critical role in dendrodendritic inhibition between mitral and granule cells. Moreover, N- and P/Q type calcium channels are involved. (Isaacson JS and Strowbridge BW, 19983 ). Calcium influx through NMDA receptors can directly trigger presynatic GABA release for local dendrodendritic feedback inhibition. DDI is elicited by photorelease of caged Ca++, with and without Cd++ and Ni++. (Chen WR et al, 20001 ). Calcium influx through NMDA receptors directly evokes GABA release in granule cells. (Halabisky B et al, 20004 ).
Olfactory bulb main interneuron granule TC GABA cellDistal equivalent dendriteNMDA.NMDA receptors play a critical role in dendrodendritic inhibition between mitral and granule cells. Moreover, N- and P/Q type calcium channels are involved. (Isaacson JS and Strowbridge BW, 19983 ). Calcium influx through NMDA receptors can directly trigger presynatic GABA release for local dendrodendritic feedback inhibition. DDI is elicited by photorelease of caged Ca++, with and without Cd++ and Ni++. (Chen WR et al, 20001 ). Calcium influx through NMDA receptors directly evokes GABA release in granule cells. (Halabisky B et al, 20004 ). NMDA receptor is required for DDI (dendrodendritic inhibition) since IPSC was completely blocked by AP-5. Ineffectiveness of AMPA receptor-mediated EPSPs to activate the granule cells may be due to their intrinsic membrane properties. (Schoppa NE et al, 19982 ).

Classical References: first publications on each compartmental property; search PubMed for complete list
1.  Chen WR, Xiong W and Shepherd GM. (2000) Analysis of relations between NMDA receptors and GABA release at olfactory bulb reciprocal synapses. Neuron 25:625-33.
2.  Schoppa NE, Kinzie JM, Sahara Y, Segerson TP and Westbrook GL. (1998) Dendrodendritic inhibition in the olfactory bulb is driven by NMDA receptors. J Neurosci 18:6790-802.
3.  Isaacson JS and Strowbridge BW. (1998) Olfactory reciprocal synapses: dendritic signaling in the CNS. Neuron 20:749-61.
4.  Halabisky B, Friedman D, Radojicic M and Strowbridge BW. (2000) Calcium influx through NMDA receptors directly evokes GABA release in olfactory bulb granule cells. J Neurosci 20:5124-34.