1. Reckziegel G, Beck H, Schramm J, Elger CE and Urban BW. (1998) Electrophysiological characterization of Na+ currents in acutely isolated human hippocampal dentate granule cells. J Physiol 509 ( Pt 1):139-50.

NeuronCompartmentPropertyConnectivityNotes
Dentate gyrus granule GLU cellSomaI Na,t.With whole-cell recordings the properties of a voltage-dependent Na+ currents were investigated in 42 DGC acutely isolated from the resected hippocampus of 20 patients with therapy-refractory temporal lobe epilepsy (TLE) using the whole-cell patch-clamp technique.The kinetic properties contributed to a reduction of the Na+ currents during repetitive stimulation that was more pronounced with higher stimulation frequencies and also showed a dependence on the holding potential (Reckziegel G et al, 1998 [human]1 ). The kinetic properties of this current were studied using the whole-cell voltage-clamp method in acutely isolated cells. No significant differences were found after induction of status epilepticus (Ketelaars SO et al, 20012 ).

Classical References: first publications on each compartmental property; search PubMed for complete list
1.  Reckziegel G, Beck H, Schramm J, Elger CE and Urban BW. (1998) Electrophysiological characterization of Na+ currents in acutely isolated human hippocampal dentate granule cells. J Physiol 509 ( Pt 1):139-50.
2.  Ketelaars SO, Gorter JA, van Vliet EA, Lopes da Silva FH and Wadman WJ. (2001) Sodium currents in isolated rat CA1 pyramidal and dentate granule neurones in the post-status epilepticus model of epilepsy. Neuroscience 105:109-20.